Evidence map›Paper›PMID 35938728›Full record

ArticleMicrobiology spectrum2022

Molecular Epidemiology of Mycobacterium abscessus Isolates Recovered from German Cystic Fibrosis Patients.

Nils Wetzstein, Margo Diricks, Thomas A Kohl, Thomas A Wichelhaus, Sönke Andres, Laura Paulowski, Carsten Schwarz, Astrid Lewin, Jan Kehrmann, Barbara C Kahl and 11 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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  12. Population genetic analysis of clinicalFrontiers in cellular and infection microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 1 country.

Nils WetzsteinDepartment of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.ORCID 0000-0002-5589-4668
Margo DiricksGerman Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Thomas A KohlGerman Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.ORCID 0000-0002-1126-6803
Thomas A WichelhausInstitute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Sönke AndresGerman Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Laura PaulowskiGerman Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Carsten SchwarzDivision of Cystic Fibrosis, Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Astrid LewinUnit Mycotic and Parasitic Agents and Mycobacteria, Robert Koch Institute, Berlin, Germany.
Jan KehrmannInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID 0000-0002-1494-9191
Barbara C KahlInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Karl DichtlMax von Pettenkofer Institut, Institute of Medical Microbiology and Hygiene, Medizinische Fakultät, Ludwig-Maximilians-Universität, Munich, Germany.ORCID 0000-0001-5032-8870
Christian HügelDepartment of Respiratory Medicine and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Olaf EickmeierDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Christina SmacznyDepartment of Respiratory Medicine and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Annika SchmidtInterfaculty Institute of Microbiology and Infection Medicine Tübingen, Insitute for Medical Microbiology and Hygiene, University Hospital Tübingen, Tübingen, Germany.
Stefan ZimmermannDepartment of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, Heidelberg, Germany.
Lutz NährlichDepartment of Pediatrics, Justus-Liebig-University Giessen, Giessen, Germany.
Sylvia HafkemeyerMukoviszidose Institut, gemeinnützige Gesellschaft für Forschung und Therapieentwicklung mbH, Bonn, Germany.
Stefan NiemannGerman Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Florian P Maurer *German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.ORCID 0000-0001-8353-5964
Michael Hogardt *Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.ORCID 0000-0002-0742-950X
Goethe University Frankfurt · DEGerman Center for Infection Research · DEInstitute of Medical Microbiology and Hygiene · DECharité - Universitätsmedizin Berlin · DEHeidelberg University · DEJustus-Liebig-Universität Gießen · DERobert Koch Institute · DEThe Cystic Fibrosis Institute · DEUniversität Hamburg · DEUniversity Hospital Münster · DEUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections due to Mycobacterium abscessus are a major cause of mortality and morbidity in cystic fibrosis (CF) patients. Furthermore, M. abscessus has been suspected to be involved in person-to-person transmissions. In 2016, dominant global clonal complexes (DCCs) that occur worldwide among CF patients have been described. To elucidate the epidemiological situation of M. abscessus among CF patients in Germany and to put these data into a global context, we performed whole-genome sequencing of a set of 154 M. abscessus isolates from 123 German patients treated in 14 CF centers. We used MTBseq pipeline to identify clusters of closely related isolates and correlate those with global findings. Genotypic drug susceptibility for macrolides and aminoglycosides was assessed by characterization of the

Indexed as

Cystic FibrosisMycobacterium abscessusMycobacterium Infections, NontuberculousAnti-Bacterial AgentsHumansMolecular EpidemiologyPhylogenyAnti-Bacterial Agentscystic fibrosisdominant circulating clonesGerman CF registryhospital transmissionMycobacterium abscessusnontuberculous mycobacteriawhole-genome sequencing

Identifiers

PMID35938728
PMCPMC9431180
OpenAlexW4290649039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.