Evidence map›Paper›PMID 35938719›Full record

ArticlemSystems2022

Phylogenomic Diversity Elucidates Mechanistic Insights into Lyme Borreliae-Host Association.

Matthew Combs, Ashley L Marcinkiewicz, Alan P Dupuis, April D Davis, Patricia Lederman, Tristan A Nowak, Jessica L Stout, Klemen Strle, Volker Fingerle, Gabriele Margos and 4 more

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. The niche ofOne health (Amsterdam, Netherlands) · 2026
    Article
  3. Article
  4. Article
  5. Minor Hosts Have a Major Impact on the Enzootic Transmission of Borrelia burgdorferi.The American journal of tropical medicine and hygiene · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Differential Resistance ofPathogens (Basel, Switzerland) · 2023
    Article
  11. Structural evolution of an immune evasion determinant shapes pathogen host tropism.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Matthew CombsDepartment of Ecology, Evolution, and Environmental Biology, Columbia Universitygrid.21729.3f, New York, New York, USA.
Ashley L MarcinkiewiczDivision of Infectious Diseases, Wadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Alan P DupuisDivision of Infectious Diseases, Wadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
April D DavisDivision of Infectious Diseases, Wadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Patricia LedermanDivision of Infectious Diseases, Wadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Tristan A NowakDivision of Infectious Diseases, Wadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Jessica L StoutDivision of Infectious Diseases, Wadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Klemen StrleDivision of Infectious Diseases, Wadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Volker FingerleGerman National Reference Centre for Borrelia, Bavarian Health and Food Safety Authority, Oberschleissheim, Germany.
Gabriele MargosGerman National Reference Centre for Borrelia, Bavarian Health and Food Safety Authority, Oberschleissheim, Germany.
Alexander T CiotaDivision of Infectious Diseases, Wadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Maria A Diuk-WasserDepartment of Ecology, Evolution, and Environmental Biology, Columbia Universitygrid.21729.3f, New York, New York, USA.
Sergios-Orestis KolokotronisDepartment of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.ORCID 0000-0003-3309-8465
Yi-Pin LinDivision of Infectious Diseases, Wadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.ORCID 0000-0002-5240-2031
New York State Department of Health · USSUNY Downstate Health Sciences University · USColumbia University · US

Funding

Identification of the mechanism of protection against a B. burgdorferi protein CspZ for the prevention of Lyme diseaseR21AI144891 · NIAID · WADSWORTH CENTER · PI BOTTAZZI, MARIA ELENA, LIN, YI-PIN · 2020 to 2021
$441k
NIAID NIH HHS R21 AI144891
6 · The paper itself

Abstract

Host association-the selective adaptation of pathogens to specific host species-evolves through constant interactions between host and pathogens, leaving a lot yet to be discovered on immunological mechanisms and genomic determinants. The causative agents of Lyme disease (LD) are spirochete bacteria composed of multiple species of the Borrelia burgdorferi

Indexed as

BorreliaBorrelia burgdorferiLyme DiseaseComplement System ProteinsHumansPhylogenyComplement System ProteinsBorreliacomplementhost associationphylogenomicsplasmid diversity

Identifiers

PMID35938719
PMCPMC9426539
OpenAlexW4290649235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.