Evidence map›Paper›PMID 35938676›Full record

ArticleAmerican journal of physiology. Cell physiology2022

Characterization of TRPV4-mediated signaling pathways in an optimized human choroid plexus epithelial cell line.

Louise Hulme, Alexandra Hochstetler, Christian Schwerk, Horst Schroten, Hiroshi Ishikawa, Chun-Yu Tung, Benjamin Perrin, Bonnie Blazer-Yost

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

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  13. Consideration of Kinase Inhibitors for the Treatment of Hydrocephalus.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Following Ussing's legacy: from amphibian models to mammalian kidney and brain.American journal of physiology. Cell physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Louise HulmeDepartment of Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana.
Alexandra HochstetlerDepartment of Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana.
Christian SchwerkDepartment of Pediatrics, Pediatric Infectious Diseases, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0002-1706-0259
Horst SchrotenDepartment of Pediatrics, Pediatric Infectious Diseases, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Hiroshi IshikawaDepartment of Neurosurgery, Laboratory of Clinical Regenerative Medicine, University of Tsukuba, Ibaraki, Japan.
Chun-Yu TungDepartment of Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana.
Benjamin PerrinDepartment of Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana.
Bonnie Blazer-YostDepartment of Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana.ORCID 0000-0002-1899-4555
University of Indianapolis · USHeidelberg University · DEUniversity of Tsukuba · JP

Funding

Department of Defense Investigator Initiated Research Award X81XWH-16-PRMRP-IIRA
6 · The paper itself

Abstract

The objectives of these studies were twofold:

Indexed as

Choroid PlexusPhosphatidylinositol 3-KinasesBlood-Brain BarrierCell LineEpithelial CellsHumansMembrane Transport ProteinsSignal TransductionTRPV Cation ChannelsMembrane Transport ProteinsPhosphatidylinositol 3-KinasesTRPV4 protein, humanTRPV Cation Channelsblood-cerebrospinal fluid barrierchoroid plexushuman choroid plexus cell linetransepithelial transporttransient potential vanilloid receptor 4

Identifiers

PMID35938676
PMCPMC9744646
OpenAlexW4290653868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.