Evidence map›Paper›PMID 35938597›Full record

Trial reportHIV research & clinical practice2022

Adaption of an ongoing clinical trial to quickly respond to gaps in changing international recommendations: the experience of D

Emmanuelle Papot, Simone Jacoby, Dona Arlinda, Anchalee Avihingsanon, Iskandar Azwa, Margaret Borok, Dannae Brown, Mohamed Cissé, Sounkalo Dao, Nnakelu Eriobu and 15 more

Open access · greenAbstract readClinical Trial, Phase IIIEquivalence TrialRandomized Controlled Trial
PubMed Full text at PMC
In one paragraph

Trial report in HIV research & clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 11 countries.

Emmanuelle PapotTherapeutic and Vaccine Research Program, The Kirby Institute, University of New South Wales Sydney, Sydney, NSW, Australia.ORCID 0000-0003-2782-0263
Simone JacobyTherapeutic and Vaccine Research Program, The Kirby Institute, University of New South Wales Sydney, Sydney, NSW, Australia.
Dona ArlindaIndonesia Research Partnership on Infectious Disease, Jakarta, Indonesia.
Anchalee AvihingsanonThe HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Iskandar AzwaInfectious Diseases Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Margaret BorokUniversity of Zimbabwe Clinical Research Centre, Harare, Zimbabwe.
Dannae BrownGlobal Medical, ViiV Healthcare, Abbotsford, Australia.
Mohamed CisséFaculté des Sciences et techniques de la santé de l'Université Gamal Abdel Nasser de Conakry, University hospital of Donka, Conakry, Guinea.ORCID 0000-0002-6859-8745
Sounkalo DaoUniversity Clinical Research Centre, Bamako, Mali.
Nnakelu EriobuInstitute of Human Virology, Abuja, Nigeria.
Richard KaplanDesmond Tutu Health Foundation, Cape Town, South Africa.
Muhammad KaryanaIndonesia Research Partnership on Infectious Disease, Jakarta, Indonesia.
Nagalingeswaran KumarasamyChennai Antiviral Research and Treatment Clinical Research Site, Infectious Diseases Medical Centre, Voluntary Health Services, Chennai, India.
Johnnie LeeGlobal Medical Affairs, Global Public Health, Janssen Pharmaceutical companies of Johnson & Johnson, Plainfield, NJ, USA.
Marcelo H LossoCoordinación en Investigación Clínica Académica en Latinoamérica Fundación IBIS Buenos Aires, Buenos Aires, Argentina.
Gail V MatthewsTherapeutic and Vaccine Research Program, The Kirby Institute, University of New South Wales Sydney, Sydney, NSW, Australia.
Leonardo PerelisCoordinación en Investigación Clínica Académica en Latinoamérica Fundación IBIS Buenos Aires, Buenos Aires, Argentina.
Carmen Perez-CasasUnitaid, Geneva, Switzerland.
Kiat RuxrungthamThe HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Melynda WatkinsProduct Development and Regulatory Affairs, Clinton Health Access Initiative, Boston, MA, USA.
H Clifford LaneNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Anthony KelleherImmunovirology and Pathogenesis Program, The Kirby Institute, University of New South Wales Sydney, Sydney,Australia.
Matthew LawBiostatistics and Databases Program, The Kirby Institute, University of New South Wales Sydney, Sydney,Australia.
Mark N PolizzottoTherapeutic and Vaccine Research Program, The Kirby Institute, University of New South Wales Sydney, Sydney, NSW, Australia.ORCID 0000-0002-6446-183X
D2EFT Study Group
UNSW Sydney · AUEstudios Clínicos Latinoamérica · ARHIV Netherlands Australia Thailand Research Collaboration · THClinton Health Access Initiative · USDesmond Tutu HIV Foundation · ZAInstitute of Human Virology · NGNational Institutes of Health · USSt Vincent's Hospital · AUUnitaid · CHUniversity of Bamako · MLUniversity of Malaya · MYUniversity of Zimbabwe · ZWVoluntary Health Services Hospital · IN

Funding

NCI NIH HHS HHSN261200800001ENCI NIH HHS HHSN261201500003I
6 · The paper itself

Abstract

A rapidly changing landscape of antiretrovirals and their procurement at scale has permitted the evaluation of new optimised second-line antiretroviral therapy (ART) in low- and middle-income countries. D

Indexed as

Anti-HIV AgentsHIV InfectionsDarunavirDrug Therapy, CombinationHumansRetrospective StudiesReverse Transcriptase InhibitorsViral LoadAnti-HIV AgentsDarunavirReverse Transcriptase Inhibitorsdrug-sparing regimensfixed-dose combinationsHIVMAMSrandomised-clinical trialTLD

Identifiers

PMID35938597
PMCPMC10029359
OpenAlexW4291021314

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.