ArticleCytometry. Part A : the journal of the International Society for Analytical Cytology2023
Long-term effects of Pfizer-BioNTech COVID-19 vaccinations on platelets.
Article in Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Single-pixel imaging flow cytometry for biomedical research.Inflammation and regeneration · 2025Review
- Unique Features and Collateral Immune Effects of mRNA-LNP COVID-19 Vaccines: Plausible Mechanisms of Adverse Events and Complications.Pharmaceutics · 2025Review
- Multisystem Endothelial Inflammation: A Key Driver of Adverse Events Following mRNA-Containing COVID-19 Vaccines.Vaccines · 2025Review
- Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets.Nature communications · 2025Article
- Real-time intelligent classification of COVID-19 and thrombosis via massive image-based analysis of platelet aggregates.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2023Article
- Thrombotic outcomes in patients in a large clinical enterprise following COVID-19 vaccination.Journal of thrombosis and thrombolysis · 2023Article
- Head-to-head comparison of four COVID-19 vaccines on platelet activation, coagulation and inflammation. The TREASURE study.Thrombosis research · 2023Article
- Long-term effects of Pfizer-BioNTech COVID-19 vaccinations on platelets.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2023Article
- Pathophysiological mechanisms of thrombosis in acute and long COVID-19.Frontiers in immunology · 2022Review
- People having hematological disorders and hypercoagulability state need extra precautions because of the increased risk of thrombosis after COVID-19 vaccination.Frontiers in medicine · 2022Article
- Increased platelet-neutrophil aggregate ratio after severe acute respiratory syndrome coronavirus 2 vaccination and severe infection.Science progressObservational
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Authors and funding
15 authors.
Funding
Abstract
There is a global concern about the safety of COVID-19 vaccines associated with platelet function. However, their long-term effects on overall platelet activity remain poorly understood. Here we address this problem by image-based single-cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer-BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet-leukocyte interaction was insignificant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.