Evidence map›Paper›PMID 35938245›Full record

ArticleJournal of Alzheimer's disease : JAD2022

Neuropsychological and Neuroanatomical Features of Patients with Behavioral/Dysexecutive Variant Alzheimer's Disease (AD): A Comparison to Behavioral Variant Frontotemporal Dementia and Amnestic AD Groups.

Sophia Dominguez Perez, Jeffrey S Phillips, Catherine Norise, Nikolas G Kinney, Prerana Vaddi, Amy Halpin, Katya Rascovsky, David J Irwin, Corey T McMillan, Long Xie and 5 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Sophia Dominguez PerezPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA, USA.
Jeffrey S PhillipsPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA, USA.
Catherine NoriseDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nikolas G KinneyPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA, USA.
Prerana VaddiPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA, USA.
Amy HalpinPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA, USA.
Katya RascovskyPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA, USA.
David J IrwinPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA, USA.
Corey T McMillanPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA, USA.
Long XieDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Laura E M WisseDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Paul A YushkevichDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dorina KallogjeriDepartment of Otolaryngology, Washington University, St. Louis, MO, USA.
Murray GrossmanPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA, USA.
Katheryn A Q CousinsPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USLund University · SEUniversity of Connecticut · USWashington University in St. Louis · US

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
Understanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI David John Irwin, Corey T McMillan · 2020 to 2026
$18.8M
Spreading Tau Pathology in Non-Amnestic Alzheimer's DiseaseR01AG054519 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jeffrey S Phillips · 2018 to 2026
$7.4M
Biological Aging Contributions to Molecular Pathology and NeurodegenerationR01AG066152 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MCMILLAN, COREY T · 2019 to 2023
$3.8M
Microscopic and Large-Scale Networks of Molecular Pathology in Frontotemporal Lobar DegenerationR01NS109260 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI IRWIN, DAVID JOHN · 2019 to 2023
$3.8M
A Network Neuroscience Investigation of Disease Spread in Non-Amnestic Mild Cognitive ImpairmentK01AG061277 · NIA · UNIVERSITY OF PENNSYLVANIA · PI PHILLIPS, JEFFREY S · 2019 to 2023
$583k
NIA NIH HHS K01 AG061277NIA NIH HHS P01 AG017586NIA NIH HHS P01 AG066597NIA NIH HHS R01 AG054519NIA NIH HHS R01 AG066152NINDS NIH HHS R01 NS109260
6 · The paper itself

Abstract

backgroundAn understudied variant of Alzheimer's disease (AD), the behavioral/dysexecutive variant of AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy.

objectiveThis study characterizes the neuropsychological and neuroanatomical features associated with bvAD by comparing it to behavioral variant frontotemporal dementia (bvFTD), amnestic AD (aAD), and subjects with normal cognition.

methodsSubjects included 16 bvAD, 67 bvFTD, 18 aAD patients, and 26 healthy controls. Neuropsychological assessment and MRI data were compared between these groups.

resultsCompared to bvFTD, bvAD showed more significant visuospatial impairments (Rey Figure copy and recall), more irritability (Neuropsychological Inventory), and equivalent verbal memory (Philadelphia Verbal Learning Test). Compared to aAD, bvAD indicated more executive dysfunction (F-letter fluency) and better visuospatial performance. Neuroimaging analysis found that bvAD showed cortical thinning relative to bvFTD posteriorly in left temporal-occipital regions; bvFTD had cortical thinning relative to bvAD in left inferior frontal cortex. bvAD had cortical thinning relative to aAD in prefrontal and anterior temporal regions. All patient groups had lower volumes than controls in both anterior and posterior hippocampus. However, bvAD patients had higher average volume than aAD patients in posterior hippocampus and higher volume than bvFTD patients in anterior hippocampus after adjustment for age and intracranial volume.

conclusionFindings demonstrated that underlying pathology mediates disease presentation in bvAD and bvFTD.

Indexed as

Alzheimer DiseaseFrontotemporal DementiaCerebral Cortical ThinningCognitionHumansMagnetic Resonance ImagingNeuropsychological TestsAlzheimer’s diseasebehavioralbehavioral variant frontotemporal dementiacognitive domainscortical thinningfrontal varianthippocampal volumesneuropsychiatric symptoms

Identifiers

PMID35938245
PMCPMC10117623
OpenAlexW4289444518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.