Evidence map›Paper›PMID 35938071›Full record

ArticleBrain communications2022

Quantification of individual remyelination during short-term disease course by synthetic magnetic resonance imaging.

Ruth Schneider, Britta Matusche, Theodoros Ladopoulos, Ilya Ayzenberg, Anne Sophie Biesalski, Ralf Gold, Barbara Bellenberg, Carsten Lukas

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Association between cardiorespiratory fitness and total brain myelin volume among older adults.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025
    Article
  4. Synthetic MRI in Progressive MS: Associations with Disability.AJNR. American journal of neuroradiology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Rapid Estimation of Myelin for Diagnostic Imaging and Quantification of Therapy Responses in Multiple Sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ruth SchneiderDepartment of Neurology, St Josef Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.ORCID https://orcid.org/0000-0002-0997-2725
Britta MatuscheInstitute of Neuroradiology, St Josef Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
Theodoros LadopoulosDepartment of Neurology, St Josef Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
Ilya AyzenbergDepartment of Neurology, St Josef Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
Anne Sophie BiesalskiDepartment of Neurology, St Josef Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
Ralf GoldDepartment of Neurology, St Josef Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
Barbara BellenbergInstitute of Neuroradiology, St Josef Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
Carsten LukasInstitute of Neuroradiology, St Josef Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.
St. Josef-Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MRI is an important diagnostic tool for evaluation of myelin content in multiple sclerosis and other CNS diseases, being especially relevant for studies investigating remyelinating pharmacotherapies. In this study, we evaluated a new synthetic MRI-based myelin estimation in methylenetetrahydrofolate reductase deficiency as a treatable primary demyelinating disorder and compared this method with established diffusion tensor imaging in both methylenetetrahydrofolate reductase deficiency patients and healthy controls. This is the first synthetic MRI-based

Indexed as

diffusion MRIMTHFRremyelinationsynthetic MRI

Identifiers

PMID35938071
PMCPMC9351729
OpenAlexW4283649730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.