Evidence map›Paper›PMID 35937947›Full record

ArticleDisease markers2022

Genomic Mutation Landscape of Primary Breast Lymphoma: Next-Generation Sequencing Analysis.

Wenqi Zhang, Chen Huang, Jingjing Liu, Lili Wu, Huichao Zhang, Xiaolin Wu, Lianjing Wang, Weijing Li, Wei Liu, Lihong Liu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Wenqi ZhangDepartment of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000 Hebei, China.ORCID https://orcid.org/0000-0002-6715-5387
Chen HuangDepartment of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000 Hebei, China.ORCID https://orcid.org/0000-0002-7324-0596
Jingjing LiuResearch Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000 Hebei, China.ORCID https://orcid.org/0000-0003-4523-6749
Lili WuDepartment of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000 Hebei, China.ORCID https://orcid.org/0000-0002-1376-2376
Huichao ZhangClinical Laboratory, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000 Hebei, China.ORCID https://orcid.org/0000-0003-3158-9324
Xiaolin WuDepartment of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000 Hebei, China.ORCID https://orcid.org/0000-0001-7908-9500
Lianjing WangDepartment of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000 Hebei, China.ORCID https://orcid.org/0000-0002-1712-1074
Weijing LiDepartment of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000 Hebei, China.ORCID https://orcid.org/0000-0002-9201-3209
Wei LiuDepartment of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000 Hebei, China.ORCID https://orcid.org/0000-0001-9006-9703
Lihong LiuDepartment of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000 Hebei, China.ORCID https://orcid.org/0000-0003-1430-7620
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary breast lymphoma (PBL) is a rare subtype of non-Hodgkin's lymphoma (NHL) with rapid progression and high risk of central nervous system metastasis. We have investigated 40 PBL patients retrospectively, and 16 of them were sequenced by a target panel of 112 genes related with lymphoma. Next-generation sequencing (NGS) identified 203 mutations spanning 35 genes and revealed seven potential protein-changing genes (PIM1, MYD88, DTX1, CD79B, KMT2D, TNFAIP3, and ITPKB) with high frequency, referring crucial roles in lymphomagenesis. Our result suggested that PIM1 mutation is correlated with the age and pathological type of PBL patients. Gene TNFAIP3 and KMT2D mutation is only related to the pathological type and primary site, respectively. These high-mutant genes detected in PBL indicated a tendency to shorten overall survival (OS) and progression-free survival (PFS), which may lead to poor prognosis. Furthermore, the nuclear factor kappa-B (NF-

Indexed as

Lymphoma, Large B-Cell, DiffuseGenomicsHigh-Throughput Nucleotide SequencingHumansMutationRetrospective Studies

Identifiers

PMID35937947
PMCPMC9355762
OpenAlexW4288712258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.