Evidence map›Paper›PMID 35937899›Full record

ArticleJournal of oral microbiology2022

Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from

Atsushi Tabata, Airi Matsumoto, Ai Fujimoto, Kazuto Ohkura, Takuya Ikeda, Hiroki Oda, Shuto Yokohata, Miho Kobayashi, Toshifumi Tomoyasu, Ayuko Takao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Journal of oral microbiology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Atsushi TabataDepartment of Bioengineering, Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University Graduate School, Tokushima, Japan.
Airi MatsumotoDepartment of Biological Science and Technology, Life System, Institute of Technology and Science, Tokushima University Graduate School, Tokushima, Japan.
Ai FujimotoDepartment of Biological Science and Technology, Life System, Institute of Technology and Science, Tokushima University Graduate School, Tokushima, Japan.
Kazuto OhkuraDivision of Clinical Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan.
Takuya IkedaDepartment of Bioengineering, Faculty of Bioscience and Bioindustry, Tokushima University, Tokushima, Japan.
Hiroki OdaDepartment of Bioengineering, Faculty of Bioscience and Bioindustry, Tokushima University, Tokushima, Japan.
Shuto YokohataDepartment of Bioengineering, Faculty of Bioscience and Bioindustry, Tokushima University, Tokushima, Japan.
Miho KobayashiDepartment of Biological Science and Technology, Life System, Institute of Technology and Science, Tokushima University Graduate School, Tokushima, Japan.
Toshifumi TomoyasuDepartment of Bioengineering, Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University Graduate School, Tokushima, Japan.
Ayuko TakaoDepartment of Oral Microbiology, School of Dental Medicine, Tsurumi University, Kanagawa, Japan.
Hisashi OhkuniResearch Institute, Health Science Research Institute East Japan Co., Ltd., Saitama, Japan.
Hideaki NagamuneDepartment of Bioengineering, Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University Graduate School, Tokushima, Japan.ORCID https://orcid.org/0000-0001-9995-7635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Some strains of Methods: Phylogenetic analysis of the CDC gene was conducted based on the web-deposited information. The molecular characteristics of CDC were investigated using a gene-deletion mutant strain and recombinant proteins expressed in Results: The gene encoding CDC found in Nm-76 and its homolog are distributed among many Conclusion: DLY functions as a hemolysin/cytolysin and erythrocyte aggregation/intercellular association molecule. This dual-function DLY could be an additional virulence factor in

Indexed as

cholesterol-dependent cytolysincytotoxicitydiscoidin domainDiscoidinolysinMitis group streptococciStreptococcus mitisvirulence factorβ-hemolysis

Identifiers

PMID35937899
PMCPMC9351568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.