ArticleFrontiers in neuroscience2022
Sex-specific stress and biobehavioral responses to human experimenters in rats.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Experimental robustness and reproducibility of the murine cecal ligation and puncture sepsis model.Intensive care medicine experimental · 2026Article
- Behavioral Convergence with Physiological Divergence: Sex Differences in Hormones but Not Social Behavior in Beagle Dogs.Animals : an open access journal from MDPI · 2026Article
- Adoption of MMPose, a general purpose pose estimation library, for animal tracking.bioRxiv : the preprint server for biology · 2026Article
- One size does not fit all: Guidelines for designing a score sheet for animal experiments - eight essential steps.Laboratory animals · 2026Article
- Generalization and extinction of platform-mediated avoidance in male and female rats.Scientific reports · 2025Article
- Sex-dependent biobehavioural responses to transgenerational maternal stress: evidence of stress resilience and vulnerability in the F3 generation.Environmental epigenetics · 2025Article
- Effects of inter-individual variability in experimenters' sensitivity and training on behavioral assessment of animal models of vestibular disorders.Frontiers in neurology · 2025Article
- The effects of moderate prenatal alcohol exposure on performance in hippocampal-sensitive spatial memory and anxiety tasks by adult male and female rat offspring.Alcohol (Fayetteville, N.Y.) · 2024Article
- Neural representation of human experimenters in the bat hippocampus.Nature neuroscience · 2024Article
- Do sheep (Ovis aries) discriminate human emotional odors?Animal cognition · 2024Article
- Behavioral sensitization and tolerance induced by repeated treatment with ketamine enantiomers in male Wistar rats.PloS one · 2024Article
- Thermal Response of Laboratory Rats (Animals : an open access journal from MDPI · 2023Article
- Rescue of Long-Term Spatial Memory by 7,8-Dihydroxyflavone in Mice with Reduced Oligodendrogenesis.eNeuro · 2023Article
- Immunotherapeutic treatment of inflammation in mice exposed to methamphetamine.Frontiers in psychiatry · 2023Article
- 7,8-dihydroxyflavone enhances long-term spatial memory and alters brain volume in wildtype mice.Frontiers in systems neuroscience · 2023Article
- Thermoregulatory dynamics reveal sex-specific inflammatory responses to experimental autoimmune encephalomyelitis in mice: Implications for multiple sclerosis-induced fatigue in females.Brain, behavior, & immunity - health · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Important factors influencing the outcome of animal experiments in preclinical research are often overlooked. In the current study, the reaction of female and male rats toward the biological sex of a human experimenter was investigated in terms of anxiety-like behaviors and physiological stress responses, as measured by infrared (IR) thermography, circulating corticosterone (CORT) and oxytocin levels. Female rats displayed consistently exacerbated anxiety-related behaviors along with elevated body surface temperature during repeated exposure to male experimenters. Experimental stress further intensified thermal responses to a male experimenter, especially in female rats. The behavioral responses to a male experimenter in females were associated with higher circulating CORT and lower oxytocin levels. Similar responses were induced by a T-shirt worn by a human male. The findings suggest that psychophysiological responses of female rats to a male experimenter are influenced by both visual and olfactory cues. The results emphasize the need to not only consider sex differences in experimental animals, but also standardize and report the experimenter's biological sex to avoid ambiguity in the generation and interpretation of results.
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