ArticleFrontiers in neuroscience2022
Differences in neuroanatomy and functional connectivity between motor subtypes of Parkinson's disease.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Exploratory radiomics analysis of T1-weighted and FLAIR MRI in relation to Parkinson's disease motor subtypes.Frontiers in neurology · 2026Article
- Effect of radical prostatectomy on anxiety, depression, and quality of life in patients diagnosed with prostate cancer.World journal of psychiatry · 2025Article
- Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation-Wide Multicenter Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Impact of phakic intraocular lens implantation on anxiety and depression in patients with high myopia.World journal of psychiatry · 2025Article
- Influence of standardized evidence-based nursing practices on mental state and adverse effects in patients undergoing endoscopic colon polypectomy.World journal of gastrointestinal surgery · 2025Article
- Clinical effect of enhanced recovery after surgery based on multidisciplinary collaboration model in postoperative gastric cancer surgery.World journal of gastrointestinal surgery · 2025Article
- Neuroimaging correlates of postural instability in Parkinson's disease.Journal of neurology · 2024Article
- Simple biomarkers to distinguish Parkinson's disease from its mimics in clinical practice: a comprehensive review and future directions.Frontiers in neurology · 2024Review
- Altered connectivity between frontal cortex and supplementary motor area in various types of Parkinson's disease.American journal of translational research · 2024Article
- Regional homogeneity and functional connectivity of freezing of gait conversion in Parkinson's disease.Frontiers in aging neuroscience · 2023Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The "postural instability/gait difficulty" (PIGD) and "tremor-dominant" (TD) motor subtypes of Parkinson's disease (PD) differ in their clinical manifestations. The neurological basis of these differences is unclear. Methods: We performed voxel-based morphometric analysis and measured amplitudes of low-frequency fluctuation (ALFF) on 87 PIGD patients and 51 TD patients. We complemented this neuroanatomical comparison with seed-to-voxel analysis to explore differences in functional connectivity. Results: The PIGD group showed significantly smaller gray matter volume in the medial frontal gyrus (mainly on the right side) than the TD group. Across all patients, gray matter volume in the medial frontal gyrus correlated negatively with severity of PIGD symptoms after controlling for age ( Conclusion: Postural instability/gait difficulty may be associated with smaller gray matter volume in medial frontal gyrus than TD, as well as with greater functional connectivity between the right superior frontal gyrus and occipital cortex. These results may help explain the clinical differences between the two motor subtypes of PD.
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