Evidence map›Paper›PMID 35937777›Full record

SynthesisJournal of the International Society of Sports Nutrition2022

The impact of nutrition on tendon health and tendinopathy: a systematic review.

Aveline Hijlkema, Caroline Roozenboom, Marco Mensink, Johannes Zwerver

Registry-linked trialOpen access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Journal of the International Society of Sports Nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06379997 (Efficacy of Oral Hyaluronic Acid and Collagen Supplementation Compared With Hyaluronic Acid Infiltration Treatment in Rotator Cuff Tendinopathies), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06379997 narecruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy of Oral Hyaluronic Acid and Collagen Supplementation Compared With Hyaluronic Acid Infiltration Treatment in Rotator Cuff Tendinopathies: A Prospective Study

TypeinterventionalSponsorI.R.C.C.S. Fondazione Santa LuciaRan2024 to 2025Enrolled50ConditionsTendinitis of Shoulder, Hyaluronic Acid, Dietary Supplements, Shoulder PainArmsCollagen, Hyaluronic Acid, Vitamin C, and Manganese, Intra-articular infiltration
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Outcomes of Arthroscopic Rotator Cuff Repair after Bariatric Surgery.Orthopaedic journal of sports medicine · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. The combination of hyaluronic acids and collagen boosts human Achilles tendon-derived cell escape from inflammation and matrix remodeling in vitro.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  10. Article
  11. Changes in Tendon Thickness After Chondrovita FITInternational journal of environmental research and public health · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. [Research on Runx2 gene induced differentiation of human amniotic mesenchymal stem cells into ligament fibroblastsZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Aveline HijlkemaWageningen University and Research, Division of Human Nutrition and Health, Wageningen, The Netherlands.
Caroline RoozenboomResearch Support Center, Hospital Gelderse Vallei, Ede, The Netherlands.
Marco MensinkWageningen University and Research, Division of Human Nutrition and Health, Wageningen, The Netherlands.
Johannes ZwerverHospital Gelderse Vallei, Sports Valley, Department of Sports Medicine, Ede, The Netherlands.
Wageningen University & Research · NLUniversity of Groningen · NLZiekenhuis Gelderse Vallei · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tendinopathy is a painful condition that is prevalent in athletes as well as the general human population, and whose management is challenging. Objective: This systematic review aimed to evaluate the impact of nutrition on the prevention and treatment of tendinopathy. Methods: Searches were conducted in PubMed, EMBASE, Web of Science, and SPORTDiscus without restriction to year of publication. Studies examining the impact of exposure to nutrient intake in an adult human population on 1) prevalence/incidence of tendinopathy, 2) clinical outcomes of tendinopathy, 3) structural changes in the tendon by imaging modalities. Experimental and observational study designs written in English, Dutch, or German were eligible. Results: Nineteen studies met the inclusion criteria. The effects of the habitual diet were investigated in one study. Four studies examined the effects of exposure to alcohol. Alcohol consumption can be a potential risk factor associated with Achilles tendinopathy and rotator cuff tears, although findings were inconsistent. The use of dietary supplements was examined in fourteen studies. Among these, collagen-derived peptides were most often part of the supplements evaluated. Combining training and dietary supplements seems to induce better clinical and functional outcomes in tendinopathy. Conclusion: This review demonstrates the paucity of high-quality studies and a wide variety among studies regarding nutrients, tendon location, study population, and reported outcome measures. Individual studies showed promising clinical implications for the use of dietary supplements, particularly those containing collagen-derived peptides. However, giving any definitive dietary recommendations on the prevention and treatment of tendinopathy remains elusive.

Indexed as

Achilles TendonTendinopathyAdultDietDietary SupplementsHumansNutritional StatusObservational Studies as TopiccollagendietsupplementstendinopathyTendon

Identifiers

PMID35937777
PMCPMC9354648
OpenAlexW4289653891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.