Evidence map›Paper›PMID 35937500›Full record

ArticleOncotarget2022

Diverse geroprotectors differently affect a mechanism linking cellular aging to cellular quiescence in budding yeast.

Anna Leonov, Rachel Feldman, Amanda Piano, Anthony Arlia-Ciommo, Jennifer Anne Baratang Junio, Emmanuel Orfanos, Tala Tafakori, Vicky Lutchman, Karamat Mohammad, Sarah Elsaser and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Anna LeonovDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Rachel FeldmanDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Amanda PianoDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Anthony Arlia-CiommoDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Jennifer Anne Baratang JunioDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Emmanuel OrfanosDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Tala TafakoriDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Vicky LutchmanDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Karamat MohammadDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Sarah ElsaserDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Sandra OrfaliDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Harshvardhan RajenDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Vladimir I TitorenkoDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Concordia University · CA

Funding

CIHR
6 · The paper itself

Abstract

We propose a hypothesis of a mechanism linking cellular aging to cellular quiescence in chronologically aging budding yeast. Our hypothesis posits that this mechanism integrates four different processes, all of which are initiated after yeast cells cultured in a medium initially containing glucose consume it. Quiescent cells that develop in these cultures can be separated into the high- and low-density sub-populations of different buoyant densities. Process 1 of the proposed mechanism consists of a cell-cycle arrest in the G

Indexed as

Saccharomyces cerevisiaeSaccharomycetalesCellular SenescenceGlucoseHumansSenotherapeuticsTrehaloseGlucoseSenotherapeuticsTrehalosecellular agingcellular quiescencegeroprotectorsgerotargetslongevity

Identifiers

PMID35937500
PMCPMC9348708
OpenAlexW4288095953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.