ArticleMovement disorders clinical practice2022
Benefits and Risks of a Staged-Bilateral VIM Versus Unilateral VIM DBS for Essential Tremor.
Article in Movement disorders clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- One Side or Two? A Systematic Review of Deep Brain Stimulation Approaches in Movement Disorders.Movement disorders clinical practice · 2025Pooled it
- Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound for Treating Essential Tremor: Systematic Review and Meta-Analysis.Movement disorders clinical practice · 2026Review
- Late-Onset Ataxia after Thalamic Deep Brain Stimulation for Tremor Linked to Therapy Escape.Movement disorders clinical practice · 2026Observational
- Natural disease progression vs. DBS-related worsening in essential tremor.medRxiv : the preprint server for health sciences · 2025Article
- Comparative efficacy of PSA and VIM deep brain stimulation in essential tremor: a network and multilevel meta-analysis.Neurosurgical review · 2025Review
- Effect of Thalamic versus Pallidal Deep Brain Stimulation on Head Tremor in Dystonic and Essential Tremor Patients-A Retrospective Video-Blinded Study.Movement disorders clinical practice · 2024Article
- The role of the motor thalamus in deep brain stimulation for essential tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- A workflow for predicting radiofrequency-induced heating around bilateral deep brain stimulation electrodes in MRI.Medical physics · 2024Article
- An Eye on the First Surgical Side: Appreciating the Potential Impacts of a Second DBS Lead on Ipsilateral Symptoms.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Demographics of focused ultrasound thalamotomy for essential tremor and trends in deep brain stimulation surgery after its introduction in the USA.BMJ neurology open · 2024Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Despite over 30 years of clinical experience, high-quality studies on the efficacy of bilateral versus unilateral deep brain stimulation (DBS) of the ventral intermediate (VIM) nucleus of the thalamus for medically refractory essential tremor (ET) remain limited. Objectives: To compare benefits and risks of bilateral versus unilateral VIM DBS using the largest ET DBS clinical trial dataset available to date. Methods: Participants from the US St. Jude/Abbott pivotal ET DBS trial who underwent staged-bilateral VIM implantation constituted the primary cohort in this sub-analysis. Their assessments "on" DBS at six months after second-side VIM DBS implantation were compared to the assessments six months after unilateral implantation. Two control cohorts of participants with unilateral implantation only were also used for between-group comparisons. Results: The primary cohort consisted of n = 38 ET patients (22M/16F; age of 65.3 ± 9.5 years). The second side VIM-DBS resulted in a 29.6% additional improvement in the total motor CRST score ( Conclusions: In the largest ET DBS study to date, staged-bilateral VIM DBS was a highly effective treatment for ET with bilateral implantation resulting in greater reduction in total motor tremor scores when compared to unilateral stimulation alone.
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