Evidence map›Paper›PMID 35937459›Full record

ArticleCancer research communications2022

Avian Paramyxovirus 4 Antitumor Activity Leads to Complete Remissions and Long-term Protective Memory in Preclinical Melanoma and Colon Carcinoma Models.

Aryana Javaheri, Yonina Bykov, Ignacio Mena, Adolfo García-Sastre, Sara Cuadrado-Castano

Abstract read
In one paragraph

Article in Cancer research communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aryana JavaheriDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Yonina BykovDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Ignacio MenaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sara Cuadrado-CastanoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Funding

Early development of small molecule dendritic cell immunopotentiators for the treatment of solid tumorsR01CA229818 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI CHANDA, SUMIT K, GARCIA-SASTRE, ADOLFO · 2018 to 2021
$2.9M
NCI NIH HHS R01 CA229818
6 · The paper itself

Abstract

Avulaviruses represent a diverse subfamily of non-segmented negative strand RNA viruses infecting avian species worldwide. To date, 22 different serotypes have been identified in a variety of avian hosts, including wild and domestic birds. APMV-1, also known as Newcastle disease virus (NDV), is the only avulavirus that has been extensively characterized due to its relevance for the poultry industry and, more recently, its inherent oncolytic activity and potential as a cancer therapeutic. An array of both naturally-occurring and recombinant APMV-1 strains has been tested in different preclinical models and clinical trials, highlighting NDV as a promising viral agent for human cancer therapy. To date, the oncolytic potential of other closely related avulaviruses remains unknown. Here, we have examined the

Indexed as

AvulavirusCarcinomaColonic NeoplasmsMelanomaAnimalsBirdsHumansMiceNewcastle disease virusAPMV-4Avian paramyxovirus 4cancer therapyNewcastle disease virusOncolytic virus

Identifiers

PMID35937459
PMCPMC9351398

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.