Evidence map›Paper›PMID 35937408›Full record

ArticleBioMed research international2022

Correlations between Intestinal Microbiota and Clinical Characteristics in Colorectal Adenoma/Carcinoma.

Caizhao Lin, Baolong Li, Chunyi Tu, Xiaohua Chen, Min Guo

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Complete genome sequence ofMicrobiology resource announcements · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Genetic heterogeneity of colorectal cancer and the microbiome.World journal of gastrointestinal oncology · 2023
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Caizhao LinDepartment of Colorectal Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, China.ORCID https://orcid.org/0000-0001-9275-0164
Baolong LiDepartment of General Surgery, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0002-1258-650X
Chunyi TuDepartment of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province 510630, China.ORCID https://orcid.org/0000-0001-7755-1861
Xiaohua ChenDepartment of Biochemistry, Medical College of Shaoguan University, Shaoguan, Guangdong Province 512026, China.ORCID https://orcid.org/0000-0002-1555-8459
Min GuoDepartment of Oncology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.ORCID https://orcid.org/0000-0002-7260-8133
Southern Medical University · CNFirst Affiliated Hospital of Jinan University · CNShaoguan University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Most of colorectal cancer (CRC) cases are sporadic and develop along the adenoma-carcinoma sequence. Intestinal microbial dysbiosis is involved in the development of colorectal cancer. However, there are still no absolute markers predicting the progression from adenoma to carcinoma. Aims: To investigate the characteristics of intestinal microbiota in colorectal adenoma and carcinoma patients and the correlations with clinical characteristics. Methods: Fecal samples were collected from 154 colorectal carcinoma patients (CRC group), 20 colorectal adenoma patients (AD group), and 199 healthy controls (control group). The intestinal microbiota was investigated by 16S rRNA gene sequencing. Results: Compared to the healthy controls, microbial diversity was dramatically decreased in AD/CRC. At the genus level, Conclusion: Several intestinal bacteria changed along the adenoma-carcinoma sequence and might be the potential markers for the diagnosis and treatment of colorectal adenoma/carcinoma. Intestinal microbiota characteristics in CRC should account for the host factors.

Indexed as

AdenomaCarcinomaColorectal NeoplasmsGastrointestinal MicrobiomeAnimalsBacteriaCatsDysbiosisFecesHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID35937408
PMCPMC9352470
OpenAlexW4288430717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.