Evidence map›Paper›PMID 35936992›Full record

ArticleVaccine: X2022

Secreted heat shock protein gp96-Ig and OX40L-Fc combination vaccine enhances SARS-CoV-2 Spike (S) protein-specific B and T cell immune responses.

Laura Padula, Eva Fisher, Katelyn Rivas, Kristin Podack, Daniela Frasca, Jonah Kupritz, Matthew M Seavey, Padmini Jayaraman, Eric Dixon, Rahul Jasuja and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine: X, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Laura PadulaDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Eva FisherDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Katelyn RivasDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Kristin PodackDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Daniela FrascaDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Jonah KupritzDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Matthew M SeaveyHeat Biologics, Inc. Morrisville, NC, USA.
Padmini JayaramanHeat Biologics, Inc. Morrisville, NC, USA.
Eric DixonHeat Biologics, Inc. Morrisville, NC, USA.
Rahul JasujaHeat Biologics, Inc. Morrisville, NC, USA.
Natasa StrboDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.
University of Miami · USHeat Biologics (United States) · US

Funding

Medical Scientist Training ProgramT32GM112601 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LEMMON, SANDRA K. · 2017 to 2021
$1.9M
NIGMS NIH HHS T32 GM112601
6 · The paper itself

Abstract

Encouraging protection results from current mRNA-based SARS-CoV-2 vaccine platforms are primarily due to the induction of SARS- CoV-2- specific B cell antibody and CD4 + T cell. Even though, current mRNA vaccine platforms are adept in inducing SARS-CoV2-specific CD8 + T cell, much less is known about CD8 T cells contribution to the overall vaccine protection. Our allogeneic cellular vaccine, based on a secreted form of the heat-shock protein gp96-Ig, achieves high frequencies of polyclonal CD8 + T cell responses to tumor and infectious antigens through antigen cross-priming

Indexed as

AntibodyB cellsCD8 T cellsGp96Heat shock proteinOX40LSARS-CoV-2 protein STFH cellsVaccine

Identifiers

PMID35936992
PMCPMC9347141
OpenAlexW4289639888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.