A facile and chemoselectivity in synthesis of 4-chloro-N-(4-((1-hydroxy-2-methylpropan-2-yl)oxy)phenethyl)benzamide, the alcohol derivative of Bezafibrate.

Greesha N Majethia, Wahajul Haq, Ganesaratnam K Balendiran

Open access · goldAbstract read

In one paragraph

Article in Results in chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 58% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

A facile synthesis of 2-(4-((4-chlorophenyl)(hydroxy)methyl) phenoxy)-2-methylpropanoic acid: Metabolite of anti-hyperlipidemic drug Fenofibrate.Results in chemistry · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Greesha N MajethiaDepartment of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA.

Wahajul HaqDepartment of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA.

Ganesaratnam K BalendiranDepartment of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA.

Youngstown State University · US

Funding

Role of fibrate mechanism in diabetes and its complicationsR15DK085496 · NIDDK · YOUNGSTOWN STATE UNIVERSITY · PI BALENDIRAN, GANESARATNAM · 2010 to 2017

$491k

NIDDK NIH HHS R15 DK085496

6 · The paper itself

Abstract

A facile method for the reduction of carboxylic acid group of Bezafibrate, an approved drug, is described. The selective reduction of carboxylic acid group to corresponding alcohol was carried out by activation of the carboxylic acid moiety via mixed anhydride followed by the addition of stoichiometric amount of NaBH

Indexed as

BezafibrateChemoselectivityMixed anhydrideReduction of carboxylic acidSodium borohydride

Identifiers

PMID35936959

DOI10.1016/j.rechem.2022.100417

PMCPMC9352152

OpenAlexW4283711231

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.