ReviewFrontiers in physiology2022
Immune remodeling and atrial fibrillation.
Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association Between TNF-Alpha Levels and Atrial Fibrillation Outcomes: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- From Peripheral Immune Signatures to Cardiac Remodeling: Interpreting the Monocyte Axis in Hypertension-Related Atrial Fibrillation.Cardiovascular drugs and therapy · 2026Article
- Th1/Th17-Treg Imbalance in Asian Atrial Fibrillation: Subtype and Demographic Heterogeneity.JACC. Asia · 2026Article
- Osteopontin in Atrial Fibrillation and Atrial Remodeling.Journal of the American Heart Association · 2026Review
- Article
- Circadian Activity Disruption in Cardiac Remodeling Patients Underlies Autonomic Dysfunction in Heart Failure.Biomedicines · 2026Article
- Single-Nucleus RNA Sequencing Reveals SPP1Journal of cardiovascular development and disease · 2026Article
- Integration of transcriptome and mendelian randomization analyses to explore the molecular mechanisms of atrial fibrillation.Journal of cardiothoracic surgery · 2026Article
- Cellular and molecular cross-talk in atrial fibrillation: The role of non-cardiomyocytes in creating an arrhythmogenic substrate.The Journal of physiology · 2026Review
- Analysis of the Correlation Between Helper T-Lymphocyte Subsets and Atrial Fibrillation: An Observational and Mendelian Randomization Study.Cardiovascular therapeutics · 2026Observational
- Development of a predictive model for in-hospital new-onset atrial fibrillation in older adults with hypertension and acute myocardial infarction, enhanced by SHAP interpretability: a retrospective cohort study.Frontiers in medicine · 2026Article
- PVN-centered multi-omics and single-cell analyses suggest shared inflammatory and immune features in acute myocardial infarction-associated ventricular arrhythmia and atrial fibrillation.Frontiers in cardiovascular medicine · 2026Article
- Integrating machine learning and molecular docking to elucidate the mechanism of atrial fibrillation induced by di(2-ethylhexyl) phthalate.Scientific reports · 2025Article
- Single-cell RNA sequencing identifies a peripheral monocyte subpopulation and its interaction with atrial macrophages via the CCL3-CCR1 axis during atrial remodeling.Science China. Life sciences · 2025Article
- C-reactive protein-albumin-lymphocyte index and atrial fibrillation recurrence after radiofrequency ablation in heart failure.iScience · 2025Article
- Do nonsteroidal anti-inflammatory drugs increase the risk of atrial fibrillation after non-cardiac surgery? Insights from translational and clinical research.Journal of anesthesia, analgesia and critical care · 2025Review
- From Tissue to Transcriptome: A Systematic Review of Multi-Level Evidence for Immune Dysregulation in Atrial Fibrillation.Journal of clinical medicine · 2025Review
- Immune Cell Dynamics in Cardiac Diseases: Insights From Single-Cell Sequencing.Journal of cellular and molecular medicine · 2025Review
- Mechanisms underlying atrial fibrillation in chronic kidney disease.Journal of molecular and cellular cardiology · 2025Review
- Structure of Comorbidities and Causes of Death in Patients with Atrial Fibrillation and Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrial fibrillation (AF) is a highly prevalent arrhythmia that causes high morbidity and mortality. However, the underlying mechanism of AF has not been fully elucidated. Recent research has suggested that, during AF, the immune system changes considerably and interacts with the environment and cells involved in the initiation and maintenance of AF. This may provide a new direction for research and therapeutic strategies for AF. In this review, we elaborate the concept of immune remodeling based on available data in AF. Then, we highlight the complex relationships between immune remodeling and atrial electrical, structural and neural remodeling while also pointing out some research gaps in these field. Finally, we discuss several potential immunomodulatory treatments for AF. Although the heterogeneity of existing evidence makes it ambiguous to extrapolate immunomodulatory treatments for AF into the clinical practice, immune remodeling is still an evolving concept in AF pathophysiology and further studies within this field are likely to provide effective therapies for AF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.