Evidence map›Paper›PMID 35936790›Full record

ArticleFrontiers in molecular biosciences2022

Large-Scale Conformational Changes of FhaC Provide Insights Into the Two-Partner Secretion Mechanism.

Giuseppe Sicoli, Albert Konijnenberg, Jérémy Guérin, Steve Hessmann, Elise Del Nero, Oscar Hernandez-Alba, Sophie Lecher, Guillaume Rouaut, Linn Müggenburg, Hervé Vezin and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Giuseppe SicoliLaboratoire Avancé de Spectroscopie pour les Interactions, la Réactivité et l'Environnement (LASIRE), UMR CNRS 8516, Université de Lille, Lille, France.
Albert KonijnenbergBAMS Research Group, University of Antwerp, Antwerp, Belgium.
Jérémy GuérinCNRS, INSERM, Institut Pasteur de Lille, Université de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
Steve HessmannLaboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, Strasbourg, France.
Elise Del NeroLaboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, Strasbourg, France.
Oscar Hernandez-AlbaLaboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, Strasbourg, France.
Sophie LecherCNRS, INSERM, Institut Pasteur de Lille, Université de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
Guillaume RouautCNRS EMR9002 Integrative Structural Biology, Lille, France.
Linn MüggenburgCNRS EMR9002 Integrative Structural Biology, Lille, France.
Hervé VezinLaboratoire Avancé de Spectroscopie pour les Interactions, la Réactivité et l'Environnement (LASIRE), UMR CNRS 8516, Université de Lille, Lille, France.
Sarah CianféraniLaboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, Strasbourg, France.
Frank SobottBAMS Research Group, University of Antwerp, Antwerp, Belgium.
Robert SchneiderCNRS EMR9002 Integrative Structural Biology, Lille, France.
Françoise Jacob-DubuissonCNRS, INSERM, Institut Pasteur de Lille, Université de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
Centre National de la Recherche Scientifique · FRInstitut Pasteur de Lille · FRUniversité de Lille · FRUniversité de Strasbourg · FRCenter for Infection and Immunity of Lille · FRInstitut de Recherche Interdisciplinaire de Grenoble · FRInstitute of Structural and Molecular Biology · GBUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Two-Partner secretion pathway mediates protein transport across the outer membrane of Gram-negative bacteria. TpsB transporters belong to the Omp85 superfamily, whose members catalyze protein insertion into, or translocation across membranes without external energy sources. They are composed of a transmembrane β barrel preceded by two periplasmic POTRA domains that bind the incoming protein substrate. Here we used an integrative approach combining

Indexed as

EPRGram-negative bacteriamass spectrometryNMROmp85 superfamilyouter membrane proteinprotein dynamicstwo-partner secretion system

Identifiers

PMID35936790
PMCPMC9355242
OpenAlexW4286560579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.