Evidence map›Paper›PMID 35936703›Full record

ArticleFrontiers in oncology2022

Label-Free Delineation of Human Uveal Melanoma Infiltration With Pump-Probe Microscopy.

Bohan Zhang, Tengteng Yao, Yaxin Chen, Chuqiao Wang, Yongyang Bao, Zhaoyang Wang, Keke Zhao, Minbiao Ji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Bohan ZhangState Key Laboratory of Surface Physics and Department of Physics, Multiscale Research Institute of Complex Systems, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Academy for Engineering and Technology, Human Phenome Institute, Fudan University, Shanghai, China.
Tengteng YaoDepartment of Ophthalmology, The Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Yaxin ChenState Key Laboratory of Surface Physics and Department of Physics, Multiscale Research Institute of Complex Systems, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Academy for Engineering and Technology, Human Phenome Institute, Fudan University, Shanghai, China.
Chuqiao WangDepartment of Ophthalmology, The Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Yongyang BaoDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhaoyang WangDepartment of Ophthalmology, The Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Keke ZhaoDepartment of Ophthalmology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Minbiao JiState Key Laboratory of Surface Physics and Department of Physics, Multiscale Research Institute of Complex Systems, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Academy for Engineering and Technology, Human Phenome Institute, Fudan University, Shanghai, China.
Shanghai Ninth People's Hospital · CNShanghai Tenth People's Hospital · CNState Key Laboratory of Surface PhysicsFudan University · CNShanghai Children's Medical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uveal melanoma (UM) is the most frequent primary intraocular malignancy in adults, characterized by melanin depositions in melanocytes located in the uveal tract in the eyes. Differentiation of melanin species (eumelanin and pheomelanin) is crucial in the diagnosis and management of UM, yet it remains inaccessible for conventional histology. Here, we report that femtosecond time-resolved pump-probe microscopy could provide label-free and chemical-specific detection of melanin species in human UM based on their distinct transient relaxation dynamics at the subpicosecond timescale. The method is capable of delineating the interface between melanoma and paracancerous regions on various tissue conditions, including frozen sections, paraffin sections, and fresh tissues. Moreover, transcriptome sequencing was conducted to confirm the active eumelanin synthesis in UM. Our results may hold potential for sensitive detection of tumor boundaries and biomedical research on melanin metabolism in UM.

Indexed as

label-free imagingmelaninmultiphoton microscopypump-probe microscopyuveal melanoma

Identifiers

PMID35936703
PMCPMC9354715
OpenAlexW4286716283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.