Evidence map›Paper›PMID 35936213›Full record

ArticleAnnals of movement disorders2021

Morphometric mapping of the macrostructural abnormalities of midsagittal corpus callosum in Wilson's disease.

Albert Stezin, Venkateswara Reddy Reddam, Shantala Hegde, Ravi Yadav, Jitender Saini, Pramod Kumar Pal

Abstract read
In one paragraph

Article in Annals of movement disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Albert StezinDepartment of Clinical Neuroscience and Department of Neurology, Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Venkateswara Reddy ReddamDepartment of Clinical Neuroscience and Department of Neurology, Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Shantala HegdeDepartment of Neuropsychology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Ravi YadavDepartment of Clinical Neuroscience and Department of Neurology, Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Jitender SainiDepartment of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Pramod Kumar PalDepartment of Clinical Neuroscience and Department of Neurology, Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

Funding

DBT-Wellcome Trust India Alliance IA/CPHI/17/1/503348
6 · The paper itself

Abstract

Background and Purpose: The corpus callosum (CC) consists of topographically arranged white matter (WM) fibers. Previous studies have indicated the CC to be discretely involved in WD. In this study, we strived to characterize the macrostructural properties of the CC using midsagittal cross-sectional area and thickness profile measurements. Materials and Methods: This study was performed using archived magnetic resonance imaging (MRI) scans of 14 patients with WD and 14 age- and gender-matched healthy controls. Using an automated software pipeline for morphometric profiling, the midsagittal CC was segmented into five sub-regions (CC Results: The mean area was significantly different only in CC Conclusion: Morphological changes of the CC are discrete in WD. Morphometric loss of CC was associated with an earlier onset of neurological symptoms and cognitive dysfunction in WD.

Indexed as

Cognitive dysfunctioncorpus callosummagnetic resonance imagingMMSEwhite matterWilson disease

Identifiers

PMID35936213
PMCPMC7613241

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