ReviewFrontiers in medicine2022
The microbicidal potential of visible blue light in clinical medicine and public health.
Review in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The potential role of violet-blue light to preventing hospital acquired infections: a systematic review.Frontiers in public health · 2024Pooled it
- Multispectral Antimicrobial Blue Light (aBL) Systems for Continuous Decontamination of Food-Contact Surfaces and Environmental Matrices.Foods (Basel, Switzerland) · 2026Article
- Violet-Blue Light Photobiological Effect on Cultured Corneal and Pigment Retinal Cells.International journal of molecular sciences · 2026Article
- Improving the Microbiological Safety of Raw Meat Through Visible Blue-Violet Light Irradiation.Foods (Basel, Switzerland) · 2026Article
- Beyond Resistance: Tolerance and Resilience of Bacteria to Photodynamic and Oxidative Stress.International journal of molecular sciences · 2025Review
- Lights out for Superbugs: Is antimicrobial blue light a potential approach for future infection Control?Advanced drug delivery reviews · 2025Review
- Analysis of the SARS-CoV-2 inactivation mechanism using violet-blue light (405 nm).Applied and environmental microbiology · 2025Article
- 405 nm light microbicidal efficacy on Treponema pallidum spiked in ex vivo human platelets.Scientific reports · 2025Article
- Antibacterial effect of titanium oxide and cobalt-doped zinc ferrite coated stainless steel orthodontic brackets againstBiomaterial investigations in dentistry · 2025Article
- 405 nm violet-blue light inactivates hepatitis C cell culture virus (HCVcc) in ex vivo human platelet concentrates and plasma.Scientific reports · 2024Article
- Exploration of the Graphene Quantum Dots-Blue Light Combination: A Promising Treatment against Bacterial Infection.International journal of molecular sciences · 2024Article
- LOV1 protein of Pseudomonas cichorii JBC1 modulates its virulence and lifestyles in response to blue light.Scientific reports · 2024Article
- Exposure of Bladder Cancer Cells to Blue Light (λ = 453 nm) in the Presence of Riboflavin Synergistically Enhances the Cytotoxic Efficiency of Gemcitabine.International journal of molecular sciences · 2024Article
- [Clinical application of photobiomodulation in trauma repair and medical aesthetics].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2024Article
- Effectiveness of Ultra-High Irradiance Blue-Light-Emitting Diodes to ControlMicroorganisms · 2024Article
- Illuminating microflora: shedding light on the potential of blue light to modulate the cutaneous microbiome.Frontiers in cellular and infection microbiology · 2024Review
- A Combination of Blue Light at 460 nm and HMicroorganisms · 2023Article
- Controllable Preparation and Research Progress of Photosensitive Antibacterial Complex Hydrogels.Gels (Basel, Switzerland) · 2023Review
- Keep It Simple: Improving the Ex Situ Culture ofPlants (Basel, Switzerland) · 2023Article
- Effect of Different Light Wavelengths onJournal of fungi (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visible blue light of wavelengths in the 400-470 nm range has been observed to have microbicidal properties. A widely accepted hypothesis for the mechanism of microbial inactivation by visible blue light is that the light causes photoexcitation of either endogenous (present within the microbe) or, exogenous (present in the biological medium surrounding the microbe) photosensitizers such as porphyrins and flavins, which leads to the release of reactive oxygen species that subsequently manifests microbicidal activity. Some of the factors that have been observed to be associated with enhanced microbicidal action include increased duration of exposure, and either pre- or co-treatment with quinine hydrochloride. In case of bacteria, repetitive exposure to the blue light shows no significant evidence of resistance development. Additionally, visible blue light has exhibited the ability to inactivate fungal and viral pathogens and, multidrug-resistant bacteria as well as bacterial biofilms. Visible blue light has demonstrated efficacy in eliminating foodborne pathogens found on food surfaces and exposed surfaces in the food processing environment as well as in the decontamination of surfaces in the clinical environment to minimize the spread of nosocomial infections. We conclude from reviewing existing literature on the application of the blue light in clinical medicine and public health settings that this microbicidal light is emerging as a safer alternative to conventional ultraviolet light-based technologies in multiple settings. However, further comprehensive studies and thorough understanding of the mechanism of microbicidal action of this light in different scenarios is warranted to determine its place in human health and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.