Evidence map›Paper›PMID 35935760›Full record

ArticleFrontiers in medicine2022

Intrarenal Single-Cell Sequencing of Hepatitis B Virus Associated Membranous Nephropathy.

Leilin Yu, Wei Lin, Chanjuan Shen, Ting Meng, Peng Jin, Xiang Ding, Peter J Eggenhuizen, Joshua D Ooi, Rong Tang, Wannian Nie and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Leilin YuDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, China.
Wei LinDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, China.
Chanjuan ShenDepartment of Hematology, The Affiliated Zhuzhou Hospital Xiangya Medical College, Central South University, Changsha, China.
Ting MengDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, China.
Peng JinDepartment of Organ Transplantation, Xiangya Hospital, Central South University, Changsha, China.
Xiang DingDepartment of Organ Transplantation, Xiangya Hospital, Central South University, Changsha, China.
Peter J EggenhuizenCentre for Inflammatory Diseases, Monash University, Clayton, VIC, Australia.
Joshua D OoiDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, China.
Rong TangDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, China.
Wannian NieDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, China.
Xia LiDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, China.
Xiangcheng XiaoDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, China.
Yong ZhongDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNXiangya Hospital Central South University · CNMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, the pathogenesis of hepatitis B virus (HBV)-associated membranous nephropathy (MN) remains elusive. This study aimed to decipher the etiopathogenesis of HBV-associated MN by performing single-cell RNA sequencing (scRNA-seq) of kidney biopsy specimens from a patient with HBV-associated MN and two healthy individuals. We generated 4,114 intrarenal single-cell transcriptomes from the HBV-associated MN patient by scRNA-seq. Compared to healthy individuals, podocytes in the HBV-associated MN patient showed an increased expression of extracellular matrix formation-related genes, including

Indexed as

endothelial cellshepatitis B virus (HBV)membranous nephropathypodocytessingle-cell RNA sequencing

Identifiers

PMID35935760
PMCPMC9355751
OpenAlexW4286697710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.