Evidence map›Paper›PMID 35935688›Full record

ReviewJournal of advanced pharmaceutical technology & research

Analytical methods for honeybee venom characterization.

Iouraouine El Mehdi, Soraia I Falcão, Saïd Boujraf, Harandou Mustapha, Maria G Campos, Miguel Vilas-Boas

Open access · goldAbstract readReview
In one paragraph

Review in Journal of advanced pharmaceutical technology & research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Physico-Chemical and Mineral Variability ofMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Exploratory proteomic characterization ofFrontiers in pharmacology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Clinical complications in envenoming byFrontiers in immunology · 2024
    Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Iouraouine El MehdiProf. Said, Clinical Neurosciences Laboratory, Faculty of Medicine and Pharmacy; Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy, University Sidi Mohamed ben Abdellah, Fez, Morocco.
Soraia I FalcãoCentro de Investigação de Montanha, Instituto Politécnico de Bragança, Campus de Santa Apolónia, Bragança, Portugal.
Saïd BoujrafProf. Said, Clinical Neurosciences Laboratory, Faculty of Medicine and Pharmacy; Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy, University Sidi Mohamed ben Abdellah, Fez, Morocco.
Harandou MustaphaProf. Said, Clinical Neurosciences Laboratory, Faculty of Medicine and Pharmacy; Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy, University Sidi Mohamed ben Abdellah, Fez, Morocco.
Maria G CamposObservatory of Drug-Herb Interactions, Faculty of Pharmacy, University of Coimbra, Health Sciences Campus, Azinhaga de Santa Comba.
Miguel Vilas-BoasCentro de Investigação de Montanha, Instituto Politécnico de Bragança, Campus de Santa Apolónia, Bragança, Portugal.
Sidi Mohamed Ben Abdellah University · MAPolytechnic Institute of Bragança · PTUniversity of Coimbra · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery of new drugs has benefited significantly from the development of research in venomics, increasing our understanding of the envenomation processes. It has been previously reported that honeybee venom (HBV) exhibits several pharmacological activities such as anti-inflammatory, antibacterial, antimutagenic, radioprotective, and anticancer activity and may inclusively act as a complementary treatment for SARS-CoV-2. It composition consists mainly on melittin, phospholipase A2, and apamin but other constituents such as hyaluronidase, mast cell degranulating peptide and secapin are also relevant for its bioactivity. However, and because HBV is not officially recognized as a drug, until now, the international community did not establish quality standards for it. To uncover its exact composition, and boost the discovery of HBV-derived drugs, a significant number of techniques were developed. In this review, a relevant overview of the so far published analytical methods for HBV characterization is organized with the aim to accelerate its future standardization. The literature search was performed within PubMed, Google Scholar, and Science Direct by selecting specific documents and exploring HBV evaluation.

Indexed as

Analytical methodsapaminenzymesmast cell degranulating peptidepeptidesvenomics

Identifiers

PMID35935688
PMCPMC9355049
OpenAlexW4290743794

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.