ArticleFrontiers in cardiovascular medicine2022
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Compliance modulation of a soft robotic atrioventricular model of heart failure with preserved ejection fraction.Nature communications · 2026Article
- Pre-Clinical Models of Heart Failure with Preserved Ejection Fraction: Advancing Knowledge for Device Based Therapies.Annals of biomedical engineering · 2025Review
- Experiments and Simulations to Assess Exercise-Induced Pressure Drop Across Aortic Coarctations.Journal of biomechanical engineering · 2025Article
- Technological evolution ofFrontiers in physiology · 2025Review
- HeartMate 3 for Heart Failure with Preserved Ejection Fraction: In Vitro Hemodynamic Evaluation and Anatomical Fitting.Annals of biomedical engineering · 2024Article
- Miniature Implantable Left Atrial/Ventricular Pump to Treat Symptoms of Heart Failure With Preserved Ejection Fraction: A Novel Device Treatment.JACC. Basic to translational science · 2024Article
- Biosensors with left ventricular assist devices.Heart failure reviews · 2024Review
- A patient-specific echogenic soft robotic left ventricle embedded into a closed-loop cardiovascular simulator for advanced device testing.APL bioengineering · 2024Article
- Investigating the importance of left atrial compliance on fluid dynamics in a novel mock circulatory loop.Scientific reports · 2024Article
- Large animal models to study effectiveness of therapy devices in the treatment of heart failure with preserved ejection fraction (HFpEF).Heart failure reviews · 2024Review
- Case report: Personalized transcatheter approach to mid-aortic syndrome byFrontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, a novel mock circulatory loop (MCL) is presented that is capable of simulating both healthy cardiac function and Heart Failure with preserved Ejection Fraction (HFpEF). This MCL differs from others presented in the literature as it features two independently actuated heart chambers, representing the left atrium and the left ventricle. This is an important improvement over other designs as it allows for potential HFpEF treatments to be examined, not just in relation to their effect on the left ventricle but also on the left atrium. The aim of this work was to show that novel MCL designs could be developed to allow for testing of new mechanical circulatory support devices for the treatment of HFpEF. Two loop configurations are presented, one featuring hard PVC cylindrical chambers and one that features soft silicone chambers which are anatomically analogous to the native heart. We show that both MCLs are capable of simulating the onset of HFpEF with a sustained increase in diastolic pressure of 62.03% and a sustained decrease in end diastolic volume (EDV) of 14.24%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.