Evidence map›Paper›PMID 35935608›Full record

ArticleHemaSphere2022

A Phase Ib Dose-finding Study of Panobinostat and Ruxolitinib in Myelofibrosis.

Claire Harrison, Florian H Heidel, Alessandro M Vannucchi, Jean-Jacques Kiladjian, Amjad Hayat, Francesco Passamonti, Eibhlin Conneally, Thomas Kindler, Bruno Martino, Daniel B Lipka and 5 more

Open access · goldAbstract read
In one paragraph

Article in HemaSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Myelofibrosis.Blood · 2023
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 13 institutions in 6 countries.

Claire HarrisonGuy's and St. Thomas' NHS Foundation Trust, Guy's Hospital, London, United Kingdom.
Florian H HeidelInternal Medicine C, University Medicine Greifswald, Germany.
Alessandro M VannucchiCRIMM-Centro Ricerca e Innovazione delle Malattie Mieloproliferative, University of Florence, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy.
Jean-Jacques KiladjianHôpital Saint-Louis, Centre d'Investigations Cliniques, INSERM, Université de Paris, AP-HP, Paris, France.
Amjad HayatDepartment of Haematology, University Hospital Galway, Galway, Republic of Ireland.
Francesco PassamontiDivision of Hematology, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Eibhlin ConneallyDepartment of Haematology, St James Hospital, Dublin, Ireland.
Thomas KindlerDepartment of Hematology, Medical Oncology and Pneumology, University Medical Center of the Johannes Gutenberg University Mainz, Germany.
Bruno MartinoAz.Osp. Bianchi-Melacrino'-Morelli, Reggio Calabria, Italy.
Daniel B LipkaSection Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT) Heidelberg, Germany.
Tommaso StefanelliNovartis Pharma AG, Basel, Switzerland.
Pantelia RoussouNovartis Pharma AG, Basel, Switzerland.
Davide GermanoNovartis Pharma AG, Basel, Switzerland.
Jacqueline EwanNovartis Pharmaceuticals UK Limited, London, United Kingdom.
Vincent RibragInstitut Gustave Roussy, Villejuif, France.
Novartis (Switzerland) · CHAzienda ospedaliera "Bianchi-Melacrino-Morelli" · ITAzienda Ospedaliero-Universitaria Careggi · ITGuy's Hospital · GBInserm · FRInstitut Gustave Roussy · FRNational Center for Tumor Diseases · DENovartis (United Kingdom) · GBSt. James's Hospital · IEUniversitätsmedizin Greifswald · DEUniversity Hospital Galway · IEUniversity Medical Center of the Johannes Gutenberg University Mainz · DEUniversity of Insubria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID35935608
PMCPMC9348858
OpenAlexW4289528626

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.