ArticleFrontiers in pediatrics2022
Thyroid cancer in children: A multicenter international study highlighting clinical features and surgical outcomes of primary and secondary tumors.
Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Thyroid surgery in children: a single pediatric center experience.Updates in surgery · 2026Article
- Article
- Thyroid function and ultrasound surveillance in childhood cancer survivors (CCS): a position paper of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED).Journal of endocrinological investigation · 2026Review
- Endocrine late-effects in survivors of childhood and adolescence cancer: clinical management.Journal of endocrinological investigation · 2026Review
- Characteristics and outcome of pediatric and adult differentiated thyroid cancer with distant metastases.Frontiers in endocrinology · 2026Article
- Risk-adapted therapy in pediatric thyroid cancer: initial experience from a national reference program by the MET group.European thyroid journal · 2025Article
- Distant Metastases and Outcome of Pediatric Differentiated Thyroid Cancer.Journal of the Endocrine Society · 2025Article
- Thyroid Cancer in Childhood Leukemia Survivors: A Systematic Review of the Incidence and Survival Outcomes.Journal of clinical medicine · 2025Review
- Age-related characteristics in differentiated thyroid cancer: a 20-year single-center retrospective analysis in pediatric and adolescent patients.Archives of endocrinology and metabolism · 2025Article
- Thyroid Cancer in Childhood Cancer Survivors: Demographic, Clinical, Germline Genetic Characteristics, Treatment, and Outcome.Journal of clinical medicine · 2025Article
- Two Decades of Thyroid Nodule Cytology in Children: Malignancy Risk Assessment at a Tertiary Care Center.Hormone research in paediatrics · 2025Article
- Major surgical conditions of childhood and their lifelong implications: comprehensive review.BJS open · 2024Review
- Article
- Thyroid diseases in children and adolescents requiring surgical treatment-indications, techniques, results, and complications based on 10 years of the single center's own experience.Frontiers in endocrinology · 2023Article
- Intraoperative Neuromonitoring for Thyroid Surgery in Children and Adolescents: A Single Center Experience.Children (Basel, Switzerland) · 2022Article
- Papillary thyroid cancer in prepubertal patients: A report of two cases and a brief review of the literature.Medicine internationalArticle
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Authors and funding
25 authors.
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Abstract
Background: Thyroid gland malignancies are rare in pediatric patients (0.7% of tumors); only 1.8% are observed in patients aged <20 years, with a higher prevalence recorded in women and adolescents. Risk factors include genetic syndromes, MEN disorders, autoimmune diseases, and exposure to ionizing radiation. Radiotherapy is also associated with an increased risk of secondary thyroid cancer. This study describes the clinical features and surgical outcomes of primary and secondary thyroid tumors in pediatric patients. Methods: Institutional data were collected from eight international surgical oncology centers for pediatric patients with thyroid cancer between 2000 and 2020. Statistical analyses were performed using the GraphPad Prism software. Results: Among 255 total cases of thyroid cancer, only 13 (5.1%) were secondary tumors. Primary thyroid malignancies were more likely to be multifocal in origin (odds ratio [OR] 1.993, 95% confidence interval [CI].7466-5.132, Conclusions: This multicenter study demonstrated excellent survival in pediatric thyroid malignancies. Secondary tumors exhibited greater disease relapse (15.8 vs. 10.5%) and a higher incidence of surgical complications (36.8 vs. 22.2%).
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