Evidence map›Paper›PMID 35935335›Full record

ArticleFrontiers in molecular neuroscience2022

Neuroprotective Properties of Bis-Sulfonamide Derivatives Against 6-OHDA-Induced Parkinson's Model

Setthawut Apiraksattayakul, Ratchanok Pingaew, Veda Prachayasittikul, Waralee Ruankham, Papitcha Jongwachirachai, Napat Songtawee, Wilasinee Suwanjang, Tanawut Tantimongcolwat, Supaluk Prachayasittikul, Virapong Prachayasittikul and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Organosulfur Compounds: Potential Therapeutics for Parkinson's Disease.CNS & neurological disorders drug targets · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Sulfonamide Derivatives: Recent Compounds with Potent Anti-alzheimer's Disease Activity.Central nervous system agents in medicinal chemistry · 2024
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Setthawut ApiraksattayakulCenter for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Ratchanok PingaewDepartment of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand.
Veda PrachayasittikulCenter of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Waralee RuankhamCenter for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Papitcha JongwachirachaiCenter for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Napat SongtaweeDepartment of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Wilasinee SuwanjangCenter for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Tanawut TantimongcolwatCenter for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Supaluk PrachayasittikulCenter of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Virapong PrachayasittikulDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Kamonrat PhopinCenter for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Mahidol University · THSrinakharinwirot University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is considered one of the health problems in the aging society. Due to the limitations of currently available drugs in preventing disease progression, the discovery of novel neuroprotective agents has been challenged. Sulfonamide and its derivatives were reported for several biological activities. Herein, a series of 17 bis-sulfonamide derivatives were initially tested for their neuroprotective potential and cytotoxicity against the 6-hydroxydopamine (6-OHDA)-induced neuronal death in SH-SY5Y cells. Subsequently, six compounds (i.e.,

Indexed as

6-OHDAADMETbis-sulfonamidemolecular dockingParkinson's diseaseSIRT1

Identifiers

PMID35935335
PMCPMC9354714
OpenAlexW4286487501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.