ArticleAsia-Pacific journal of oncology nursing2022
Symptom clusters and their predictors in patients with lung cancer and treated with programmed cell death protein 1 immunotherapy.
Article in Asia-Pacific journal of oncology nursing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effectiveness of Interventions Based on Symptom Clusters for Symptom Burden and Quality of Life Among Cancer Patients: A Meta-Analysis of Randomized Controlled Trials.Research in nursing & health · 2026Pooled it
- Study Protocol to Characterize Symptom Experience During Immune Checkpoint Inhibitor Therapy for Cutaneous Melanoma.Nursing research · 2026Article
- Metabolic dysregulation associated with core symptom cluster in lung cancer patients undergoing chemotherapy.British journal of cancer · 2026Article
- Patient-Reported Outcomes With First-Line Immunotherapy-Based Combination Treatment for Advanced Lung Cancer: A Prospective, Multicenter, Observational Study.Thoracic cancer · 2025Observational
- The mediating effects of coping strategies between symptom clusters and quality of life in lung cancer patients undergoing immunotherapy.BMC psychiatry · 2025Article
- Article
- Symptom clusters and symptom network analysis during immunotherapy in lung cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
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10 authors.
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Abstract
Objective: The aims of this study were to examine the symptom severity and interference among patients with lung cancer treated with PD-1 immunotherapy, explore whether those symptoms were clustered together, and identify factors associated with symptom clusters. Methods: A cross-sectional study was conducted. Data were collected by demographic and clinical characteristic questionnaires and the M.D. Anderson Symptom Inventory Lung Cancer Module. Symptom clusters were identified using exploratory factor analysis, and stepwise linear regression was applied to analyze the factors affecting the symptom clusters. Results: A total of 148 patients with lung cancer treated with PD-1 immunotherapy participated in this study. The overall symptom burdens of these patients were mainly at a mild level. The patient symptom clusters identified in this study were a general cluster, a treatment-related cluster, a pulmonary cluster, a gastrointestinal cluster, and a neural cluster. The patients' Karnofsky performance status (KPS) score ( Conclusions: The symptom burdens of patients with lung cancer and treated with PD-1 immunotherapy were at a mild level and appeared to be clustered. In addition, because the symptoms that comprise a cluster are interrelated, the diagnosis and management of each symptom in a cluster should not be performed in isolation, and each symptom in a cluster should be treated either simultaneously or in an orderly manner.
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