ArticleFrontiers in microbiology2022
Progressive microbial adaptation of the bovine rumen and hindgut in response to a step-wise increase in dietary starch and the influence of phytogenic supplementation.
Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 40 citations in OpenAlex.
- Metabolome analyses of the rumen, feces and blood reveal separate and simultaneous impacts of increased dietary concentrate and hindgut starch flow in Holstein cows.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- The Dietary Inclusion of Corn and Peas Affects the Fecal Bacterial Diversity and Composition of Sarda Goats.Animals : an open access journal from MDPI · 2026Article
- Effects ofAnimals : an open access journal from MDPI · 2026Article
- Dietary 4-Hydroxy-2,5-Dimethyl-3(2H)-Furanone Supplementation in Hu Sheep: Implications on Fecal and Rumen Microbiota.Animals : an open access journal from MDPI · 2026Article
- Strategies for Reducing Antimicrobial Use in Cattle Through Gut Microbiome Modulation: A Systematic Review of Alternatives to Antibiotics.Animals : an open access journal from MDPI · 2026Review
- Targeted Livestock Metabolomics: A Review of Liquid chromatography-Mass Spectrometry-Based Approaches.Journal of agricultural and food chemistry · 2026Review
- Replacing up to 50% of Corn Silage with Triticale Silage Alters the Fecal Microbiome but Not Milk Yield or Composition in Mid-Lactation Holstein Cows.Animals : an open access journal from MDPI · 2026Article
- Effect of different levels of Fenugreek sprouts on rumen microbiota and milk yield in Hassani goats.Scientific reports · 2026Article
- Impact of differential dietary concentrations of cobalt, manganese and zinc on gastrointestinal microbiome and resistome of lactating dairy cattle.Animal microbiome · 2026Article
- Transcriptional adaptation of rumen papillae to high-grain diet reveals distinct temporal phases and SARA susceptibility signatures.Journal of animal science and biotechnology · 2026Article
- Microbiome by transcriptome interactions triggered by a switch to an alternative diet in Nellore cattle.Scientific reports · 2026Article
- Effects on Rumen Microbial Population and Serum Biochemical Responses to Guanidinoacetic Acid,Animals : an open access journal from MDPI · 2025Article
- Evaluation of esophageal tubing and buccal swabbing versus rumen cannula to characterize ruminal microbiota in cows fed contrasting diets.Scientific reports · 2025Article
- Dietary effects of organic selenium and zinc combination onJournal of advanced veterinary and animal research · 2025Article
- Subspecific variation in gut microbiota of North American bison in a sympatric setting reveals differentially abundant taxa.Animal microbiome · 2025Article
- Theabrownin combined with zearalenone suppresses colitis-associated colorectal cancer by inhibiting PI3K/AKT pathway and enhancing microbial propionate production.Scientific reports · 2025Article
- Impacts of trehalose supplementation on ruminal microbiota and productivity of Japanese Black heifers under heat-stressed conditions.Animal bioscience · 2025Article
- Alternatives to antibiotics for sustainable livestock production in the context of the One Health approach: tackling a common foe.Frontiers in veterinary science · 2025Review
- Dynamic interplay of immune response, metabolome, and microbiota in cows during high-grain feeding: insights from multi-omics analysis.Microbiology spectrum · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial composition and activity in the gastrointestinal tract (GIT) of cattle has important implications for animal health and welfare, driving the focus of research toward ways to modify their function and abundance. However, our understanding of microbial adaption to nutritional changes remains limited. The aim of this study was to examine the progressive mechanisms of adaptation in the rumen and hindgut of cattle receiving increasing amounts of starch with or without dietary supplementation of a blended phytogenic feed additive (PFA; containing menthol, thymol and eugenol). We used 16S rRNA gene amplicon sequencing to assess the microbial composition and predicted metabolic pathways in ruminal solid and liquid digesta, and feces. Furthermore, we employed targeted liquid chromatography-mass spectrometry methods to evaluate rumen fluid metabolites. Results indicated a rapid microbial adaptation to diet change, starting on the second day of starch feeding for the particle associated rumen liquid (PARL) microbes. Solid rumen digesta- and feces-associated microbes started changing from the following day. The PARL niche was the most responsive to dietary changes, with the highest number of taxa and predicted pathways affected by the increase in starch intake, as well as by the phytogenic supplementation. Despite the differences in the microbial composition and metabolic potential of the different GIT niches, all showed similar changes toward carbohydrate metabolism. Metabolite measurement confirmed the high prevalence of glucose and volatile fatty acids (VFAs) in the rumen due to the increased substrate availability and metabolic activity of the microbiota. Families
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.