ArticleNature synthesis2022
Single-atom logic for heterocycle editing.
Article in Nature synthesis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers.
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Who cites it
183 citing papers in PubMed.
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- Formal nitrogen-to-carbon replacement in isoindolines to form indenesChemical science · 2026Article
- Sulfilimines Are Azide Alternatives for Nitrene-Mediated Aromatic C-to-N Transmutation.Journal of the American Chemical Society · 2026Article
- Molecular Framework Modification in Mass Spectrometry: Atom Exchange, Insertion, and Deletion.Journal of the American Society for Mass Spectrometry · 2026Article
- Divergent and precise alkaloid remodelling with a small suite of reactions.Nature chemistry · 2026Article
- Skeletal restructuring of oxetanes through photoinduced oxygen deletion.Nature communications · 2026Article
123 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
Medicinal chemistry continues to be impacted by new synthetic methods. Particularly sought after, especially at the drug discovery stage, is the ability to enact the desired chemical transformations in a concise and chemospecific fashion. To this end, the field of organic synthesis has become captivated by the idea of 'molecular editing'-to rapidly build onto, change or prune molecules one atom at a time using transformations that are mild and selective enough to be employed at the late stages of a synthetic sequence. In this Review, the definition and categorization of a particularly promising subclass of molecular editing reactions, termed 'single-atom skeletal editing', are proposed. Although skeletal editing applies to both cyclic and acyclic compounds, this Review focuses on heterocycles, both for their centrality in medicinal chemistry and for the definitional clarity afforded by a focus on ring systems. A classification system is presented by highlighting methods (both historically important examples and recent advances) that achieve such transformations, with the goal to spark interest and inspire further development in this growing field.
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Registered trials
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