Evidence map›Paper›PMID 35935042›Full record

ReviewAdvanced pharmaceutical bulletin2022

CAR T Cells: Cancer Cell Surface Receptors Are the Target for Cancer Therapy.

Behrouz Shademan, Vahidreza Karamad, Alireza Nourazarian, Cigir Biray Avcı

Open access · diamondAbstract readReview
In one paragraph

Review in Advanced pharmaceutical bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Targets for CAR Therapy in Multiple Myeloma.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Cancers · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Behrouz ShademanDepartment of Medical Biology, Faculty of Medicine, EGE University, Izmir, Turkey.ORCID https://orcid.org/0000-0003-2663-723X
Vahidreza KaramadDepartment of Medical Biology, Faculty of Medicine, EGE University, Izmir, Turkey.
Alireza NourazarianDepartment of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran.
Cigir Biray AvcıDepartment of Medical Biology, Faculty of Medicine, EGE University, Izmir, Turkey.ORCID https://orcid.org/0000-0002-2748-3124
Ege University · TRIslamic Azad University, Khoy Branch · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy has become a prominent strategy for the treatment of cancer. A method that improves the immune system's ability to attack a tumor (Enhances antigen binding). Targeted killing of malignant cells by adoptive transfer of chimeric antigen receptor (CAR) T cells is a promising immunotherapy technique in the treatment of cancers. For this purpose, the patient's immune cells, with genetic engineering aid, are loaded with chimeric receptors that have particular antigen binding and activate cytotoxic T lymphocytes. That increases the effectiveness of immune cells and destroying cancer cells. This review discusses the basic structure and function of CAR-T cells and how antigenic targets are identified to treat different cancers and address the disadvantages of this treatment for cancer.

Indexed as

CAR-T cellImmunotherapySurface receptorsTumor microenvironment

Identifiers

PMID35935042
PMCPMC9348524
OpenAlexW3197458350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.