ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2022
Hemodynamic reserve predicts early right heart failure after LVAD implantation.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Prediction of Right Heart Failure After Left Ventricular Assist Device: Opening Pandora's Box.Reviews in cardiovascular medicine · 2025Review
- Preoperative use of intra-aortic balloon pump before left ventricular assist device implantation.JHLT open · 2025Article
- Dynamic load modulation predicts right heart tolerance of left ventricular cardiovascular assist in a porcine model of cardiogenic shock.Science translational medicine · 2024Article
- Foreword.Interventional cardiology (London, England) · 2024Article
- Prediction, prevention, and management of right ventricular failure after left ventricular assist device implantation: A comprehensive review.Frontiers in cardiovascular medicine · 2022Review
- Supporting the "forgotten" ventricle: The evolution of percutaneous RVADs.Frontiers in cardiovascular medicine · 2022Review
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20 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundEarly right heart failure (RHF) remains a major source of morbidity and mortality after left ventricular assist device (LVAD) implantation, yet efforts to predict early RHF have proven only modestly successful. Pharmacologic unloading of the left ventricle may be a risk stratification approach allowing for assessment of right ventricular and hemodynamic reserve.
methodsWe performed a multicenter, retrospective analysis of patients who had undergone continuous-flow LVAD implantation from October 2011 to April 2020. Only those who underwent vasodilator testing with nitroprusside during their preimplant right heart catheterization were included (n = 70). Multivariable logistic regression was used to determine independent predictors of early RHF as defined by Mechanical Circulatory Support-Academic Research Consortium.
resultsTwenty-seven patients experienced post-LVAD early RHF (39%). Baseline clinical characteristics were similar between patients with and without RHF. Patients without RHF, however, achieved higher peak stroke volume index (SVI) (30.1 ± 8.8 vs 21.7 ± 7.4 mL/m
conclusionPeak SVI with nitroprusside administration was independently associated with post-LVAD early RHF while resting hemodynamics were not. Vasodilator testing may prove to be a strong risk stratification tool when assessing LVAD candidacy though additional prospective validation is needed.
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