SynthesisBritish journal of anaesthesia2022
Interventions for the prevention or treatment of epidural-related maternal fever: a systematic review and meta-analysis.
Synthesis in British journal of anaesthesia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Interventions for the prevention or treatment of epidural-related maternal fever: a systematic review and meta-analysis.British journal of anaesthesia · 2022Pooled it
- Addition of Lidocaine to Ropivacaine and Sufentanil for Epidural Labour Analgesia: A Randomised Double-Blind Study on the Incidence of Epidural-Related Maternal Fever.Drug design, development and therapy · 2025Trial
- Development and validation of a multivariable logistic regression model for predicting epidural-related maternal fever during labor analgesia: A retrospective cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Machine learning for prediction of histologic chorioamnionitis (stage ≥II) in parturients receiving labor analgesia: a retrospective multicentre cohort study.Frontiers in medicine · 2026Article
- Relatively low plasma cortisol levels in parturients are associated with epidural-related maternal fever.Annals of medicine · 2025Article
- Article
- The cutaneous sympathetic blockade associated with labour epidural analgesia: a quasi-experimental study conducted during labour and after delivery.British journal of anaesthesia · 2025Article
- Maternal fever, epidural analgesia, and genetics: implications for the neonate.British journal of anaesthesia · 2025Article
- Predictive value of the neutrophil-to-lymphocyte ratio for epidural labor analgesia-associated intrapartum fever: a retrospective single-center study.BMC anesthesiology · 2025Article
- Machine Learning-Driven Intrapartum Fever Prediction: A Comprehensive Large Retrospective Cohort Study Integrating Inflammatory and Obstetric Markers.International journal of general medicine · 2025Article
- Fever in childbirth: a mini-review of epidural-related maternal fever.Frontiers in neuroscience · 2024Review
- The impact of epidural analgesia on delivery mode in Robson class 1 women: a retrospective cohort study.AJOG global reports · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidural-related maternal fever in women in labour has consequences for the mother and neonate. There has been no systematic review of preventive strategies.
methodsRCTs evaluating methods of preventing or treating epidural-related maternal fever in women in active labour were eligible. We searched MEDLINE, EMBASE, CINAHL, Web of Science, CENTRAL, and grey literature sources were searched from inception to April 2021. Two review authors independently undertook study selection. Data extraction and quality assessment was performed by a single author and checked by a second. The Cochrane Risk of Bias 2 tool was used. Meta-analyses for the primary outcome, incidence of intrapartum fever, were performed using the DerSimonian and Laird random effects model to produce summary risk ratios (RRs) with 95% confidence intervals (95% CIs).
resultsForty-two records, representing 34 studies, were included. Methods of reduced dose epidural reduced the incidence of intrapartum fever, but this was not statistically significant when six trials at high risk of bias were removed (seven trials; 857 participants; RR=0.83; 95% CI, 0.41-1.67). Alternative methods of analgesia and high-dose prophylactic systemic steroids reduced the risk of intrapartum fever compared with epidural analgesia. Prophylactic paracetamol was not effective.
conclusionsThere is no clear evidence to support the use of any individual preventative or therapeutic intervention for epidural-related maternal fever. Further research should focus on understanding the mechanism of fever development to enable RCTs of potential interventions to reduce the incidence of intrapartum fever development and the subsequent disease burden felt by the neonate. CLINICAL
trial registrationCRD42021246929.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.