Evidence map›Paper›PMID 35934083›Full record

ArticleThe Journal of allergy and clinical immunology2023

IL-4 receptor alpha signaling alters oral food challenge and immunotherapy outcomes in mice.

Varsha Ganesan, Ankit Sharma, Sunil Tomar, Charles F Schuler, Simon P Hogan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Varsha GanesanMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.
Ankit SharmaMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.
Sunil TomarMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.
Charles F SchulerMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich; Division of Allergy and Immunology, University of Michigan, Ann Arbor, Mich.
Simon P HoganMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich; Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, Mich. Electronic address: sihogan@med.umich.edu.
University of Michigan–Ann Arbor · US

Funding

Food Allergy and Goblet Cell Antigen PassagesR01AI112626 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOGAN, SIMON PATRICK, NEWBERRY, RODNEY D · 2015 to 2019
$2.4M
Pro-Type 2 Goblet Cell Antigen Passages in Food Sensitization and ReactivityR37AI112626 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIMON Patrick HOGAN, Rodney D Newberry · 2023 to 2026
$2.2M
Interleukin-9 In Experimental Intestinal AnaphylaxisR01AI073553 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI HOGAN, SIMON PATRICK · 2008 to 2011
$1.5M
Eosinophil:M2 Macrophage:CCL11 Axis in Experimental Colitis and Pediatric CorticoR01DK090119 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HOGAN, SIMON PATRICK · 2012 to 2015
$1.3M
Intestinal epithelial immunological responses and food allergen samplingR21AI138177 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOGAN, SIMON PATRICK · 2019 to 2020
$429k
NIAID NIH HHS R01 AI073553NIAID NIH HHS R01 AI112626NIAID NIH HHS R21 AI138177NIAID NIH HHS R37 AI112626NIDDK NIH HHS R01 DK090119
6 · The paper itself

Abstract

backgroundFood allergy diagnosis and management causes a number of social and emotional challenges for individuals with food allergies and their caregivers. This has led to increased interest in developing approaches to accurately predict food allergy diagnosis, severity of food allergic reactions, and treatment outcomes. However, the utility of these approaches is somewhat conflicting.

objectiveWe sought to develop and utilize a murine model that mimics the disease course of food allergy diagnosis and treatment in humans and to identify biomarkers that predict reactivity during food challenge (FC) and responsiveness during oral immunotherapy (OIT) and how these outcomes are modified by genetics.

methodsSkin-sensitized intestinal IL-9 transgenic (IL9Tg) and IL9Tg mice backcrossed onto the IL-4Rα

resultsSubcutaneous sensitization and a single intragastric allergen challenge of egg antigen to BALB/c IL9Tg mice and Il4ra

conclusionCollectively, these data indicate that single nucleotide polymorphisms in IL-4Rα can alter clinical symptoms of food allergic reactions, severity, and reactive dose during FC and OIT, and that severity of first reaction can predict the likelihood of reaction during FC in mice with IL-4Rα gain of function.

Indexed as

AllergensFood HypersensitivityAdministration, OralAnimalsBiomarkersDesensitization, ImmunologicHumansImmunotherapyMiceMice, TransgenicOvalbuminAllergensBiomarkersOvalbuminbiomarkersfood challengegeneticsIL-4Rα gain of functionoral immunotherapy

Identifiers

PMID35934083
PMCPMC11157665
OpenAlexW4289835613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.