Evidence map›Paper›PMID 35933744›Full record

ArticleBrain and language2022

Semantic network activation facilitates oral word reading in chronic aphasia.

Sara B Pillay, William L Gross, Joseph Heffernan, Diane S Book, Jeffrey R Binder

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Brain and language, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06048159 (TACS for the Recovery of Phonological STM After Stroke), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06048159 narecruitingnot on this mapstarted 2023, after this paper: background citation

TACS for the Recovery of Phonological STM After Stroke

TypeinterventionalSponsorMedical College of WisconsinRan2023 to 2033Enrolled120ConditionsStroke, AphasiaArmsHD-tACS, Sham HD-tACS
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sara B PillayDepartment of Neurology and the Center for Imaging Research, Medical College of Wisconsin, Milwaukee, WI 53226, United States. Electronic address: sapillay@mcw.edu.
William L GrossDepartment of Neurology and the Center for Imaging Research, Medical College of Wisconsin, Milwaukee, WI 53226, United States; Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Joseph HeffernanDepartment of Neurology and the Center for Imaging Research, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Diane S BookDepartment of Neurology and the Center for Imaging Research, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Jeffrey R BinderDepartment of Neurology and the Center for Imaging Research, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Medical College of Wisconsin · US

Funding

NEUROBIOLOGY OF LANGUAGE PERCEPTION--FMRI INVESTIGATIONSR01DC003681 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI HICKOK, GREGORY · 1999 to 2015
$6.9M
Neurorehabilitation and Restorative Neuroscience NetworkK12HD093427 · NICHD · GEORGETOWN UNIVERSITY · PI BREGMAN, BARBARA S, DROMERICK, ALEXANDER W · 2017 to 2021
$3.9M
FUNCTIONAL MRI OF HUMAN BRAIN LANGUAGE SYSTEMSR01NS033576 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI BINDER, JEFFREY R · 1995 to 2010
$3.5M
Institutional Career Development CoreKL2TR001438 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2015 to 2024
$2.9M
Functional MRI of Recovery in Fluent AphasiaR03NS054958 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI BINDER, JEFFREY R · 2006 to 2007
$149k
NCATS NIH HHS KL2 TR001438NICHD NIH HHS K12 HD093427NIDCD NIH HHS R01 DC003681NINDS NIH HHS R01 NS033576NINDS NIH HHS R03 NS054958
6 · The paper itself

Abstract

People with aphasia often show partial impairments on a given task. This trial-to-trial variability offers a potential window into understanding how damaged language networks function. We test the hypothesis that successful word reading in participants with phonological system damage reflects semantic system recruitment. Residual semantic and phonological networks were defined with fMRI in 21 stroke participants with phonological damage using semantic- and rhyme-matching tasks. Participants performed an oral word reading task, and activation was compared between correct and incorrect trials within the semantic and phonological networks. The results showed a significant interaction between hemisphere, network activation, and reading success. Activation in the left hemisphere semantic network was higher when participants successfully read words. Residual phonological regions showed no difference in activation between correct and incorrect trials on the word reading task. The results provide evidence that semantic processing supports successful phonological retrieval in participants with phonological impairment.

Indexed as

AphasiaReadingHumansMagnetic Resonance ImagingSemanticsSemantic WebAphasiafMRIPhonologyReorganizationSemanticsStroke

Identifiers

PMID35933744
PMCPMC9948519
OpenAlexW4289792245

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.