SynthesisSurgery today2023
Preoperative hypoalbuminemia in patients undergoing cardiac surgery: a meta-analysis.
Synthesis in Surgery today, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Prevalence and risk factors of frailty among cardiac surgery patients: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Predictive role of prognostic nutritional index and geriatric nutritional risk index for postoperative mortality risk in patients with aortic dissection: a systematic review and meta-analysis.Journal of thoracic disease · 2026Article
- Article
- Comments on: A simplified frailty assessment using three objective measures predicts mid-term outcomes after cardiac surgery.General thoracic and cardiovascular surgery · 2026Article
- A simplified frailty assessment using three objective measures predicts mid-term outcomes after cardiac surgery.General thoracic and cardiovascular surgery · 2026Observational
- Relationship between perioperative serum albumin levels and paravalvular leak after transcatheter aortic valve replacement.BMC cardiovascular disorders · 2026Observational
- Perioperative hypoalbuminemia predicts postoperative survival: a large cohort study with global context.Frontiers in medicine · 2026Article
- Prognostic value of the C-reactive protein-albumin-lymphocyte index for postoperative visual hallucinations following cardiac surgery.Frontiers in psychiatry · 2026Article
- The relationship between in-hospital mortality and Naples prognostic score in patients undergoing tricuspid valve surgery.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Long-Term Prognostic Value of the Prognostic Nutritional Index in Patients Undergoing Coronary Artery Bypass Grafting.Journal of the American Heart Association · 2025Article
- Prognostic Significance of Albumin in Modern Left Ventricular Assist Device Therapy: Relevance in the HeartMate 3 Era?Journal of clinical medicine · 2025Article
- Association between geriatric nutritional risk index and In-Hospital mortality in acute aortic dissection patients: a retrospective cohort study.BMC cardiovascular disorders · 2025Article
- Machine Learning Models With Prognostic Implications for Predicting Gastrointestinal Bleeding After Coronary Artery Bypass Grafting and Guiding Personalized Medicine: Multicenter Cohort Study.Journal of medical Internet research · 2025Article
- Assessing the Predictive Impact of Preoperative Lactate Dehydrogenase to Albumin Ratio on Outcomes Following Coronary Artery Bypass Graft Surgery.Journal of clinical medicine · 2025Article
- Development and validation of a prediction model for acute kidney injury following cardiac valve surgery.Frontiers in medicine · 2025Article
- Independent risk factors and outcomes for ventilator-associated pneumonia due to multidrug-resistant organisms after cardiac valvular surgery.Frontiers in cardiovascular medicine · 2025Article
- Pre-Transplant Hypoalbuminemia Is Not Associated With Early Key Outcomes Among Simultaneous Pancreas and Kidney Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Machine learning-based prediction of 1-year mortality using nutritional and inflammatory factors for type A acute aortic dissection with malperfusion.Frontiers in cardiovascular medicine · 2025Article
- Hepatopathy and acute kidney injury Following Corrective Cardiac Surgery with cardiopulmonary bypass pump in Pediatric with Congenital Heart Defects.ARYA atherosclerosis · 2025Article
- HALP Score as a Prognostic Biomarker in Tricuspid Valve Surgery: Association with in-Hospital and Long-Term Mortality.Journal of inflammation research · 2025Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The preoperative serum albumin level has been shown to be associated with adverse postoperative complications, meaning that hypoalbuminemia may also be a risk factor. We performed a meta-analysis to evaluate the association of serum albumin levels with survival and complication rates after cardiac surgery. Relevant articles were identified through seven databases. Twenty studies with 22553 patients (hypoalbuminemia group, n = 9903; normal group, n = 12650) who underwent cardiac surgery met the inclusion criteria after screening. The primary outcomes were that hypoalbuminemia was significantly correlated with serious long-term all-cause mortality (hazard ratio [HR]: 1.95 [1.54-2.48]; P < 0.00001) and increased mortality (risk ratio [RR] = 1.91 [1.61-2.27], P < 0.00001). Hypoalbuminemic patients with cardiopathy were more likely to suffer postoperative complications (bleeding, infections, renal injury, and others) than those whose serum albumin levels were normal. Furthermore, hypoalbuminemia increased the time in the intensive-care unit (ICU) (mean difference [MD] = 1.18 [0.49-1.87], P = 0.0008), length of hospital stay (LOS) (MD = 3.34, 95% CI: 1.88-4.80, P < 0.00001), and cardiopulmonary bypass time (CPB) (MD = 12.40 [1.13-23.66], P = 0.03). Hypoalbuminemia in patients undergoing cardiac surgery appears to have a poor all-cause mortality or increased risk of complications. Adjusted perioperative serum albumin levels and treatment strategies for this high-risk population have the potential to improve the survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.