ArticleAnnals of Saudi medicine
Features and diagnostic accuracy of fine needle aspiration cytology of thyroid nodules: retrospective study from Oman.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 16 citations in OpenAlex.
- Proteomic analysis of papillary thyroid carcinoma in the context of Hashimoto's thyroiditis.Scientific reports · 2026Article
- Integration of dual-source dual-energy CT quantitative parameters and ultrasound image features: A diagnostic method for extraglandular invasion of papillary thyroid carcinoma.Oncology letters · 2025Article
- Diagnostic Value of Fine Needle Aspiration in Diagnosis of Thyroid Nodules at the Endocrine Clinic of Hamadan City During a 10-Year Period, Iran.Journal of research in health sciences · 2025Article
- Sonoelastography in differentiating benign and malignant thyroid nodules: A histopathological correlation.Bioinformation · 2025Article
- Clear cell renal carcinoma metastasis to the thyroid gland combined with papillary thyroid carcinoma - a case report.Frontiers in oncology · 2025Article
- Multicenter Evaluation of Thyroid Nodule Size: Implications for FNA Diagnostic Accuracy and Malignancy Risk.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Article
- Prompt engineering and diagnostic accuracy of multimodal large language models in thyroid fine-needle aspiration cytology.Bioinformation · 2025Article
- The Incidence of Thyroid Cancer in Bethesda III Thyroid Nodules: A Retrospective Analysis at a Single Endocrine Surgery Center.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Needle size for thyroid fine needle aspiration cytology. A single institution experience.Frontiers in surgery · 2024Article
- Application of the Newer 2023 Bethesda System for Reporting Cytopathology of Thyroid Nodules and Estimating their Risk of Malignancy.Journal of cytologyArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
backgroundFine needle aspiration cytology (FNAC) of the thyroid has been a reliable and cost-effective method for diagnosing thyroid disorders. Since FNAC results are usually operator dependent, there is a compelling need to explore FNAC accuracy among Omanis.
objectiveDescribe cytological features of FNAC and assess FNAC accuracy compared to the postsurgical histopathology report.
designRetrospective diagnostic accuracy study
settingTertiary care center. PATIENTS AND
methodsOur study included adult Omani adult patients with thyroid nodules who underwent FNAC from 2014 to 2017 and had final pathology results for patients who underwent thyroid surgery. The results were classified according to the UK Royal college of Pathologists 'Thy' categories. Accuracy of FNAC was calculated by determining false and true positive and negative results based on histopathology findings.
main outcome measuresFNAC accuracy (sensitivity and specificity) compared to the postsurgical histopathology. SAMPLE SIZE: 867 patients with 1359 ultrasound guided FNACs of thyroid nodule; 137 underwent surgery.
resultsThe mean age of the 867 patients was 43.7 (13.3) years, with a median of 42 years, and 87.8% were females. Out of 1359 FNACs, 1001 (73.7%) were benign (Thy2), 119 (8.8%) were atypia of undetermined significance or follicular lesion of undetermined significance (Thy3a), 31 (2.3%) were follicular neoplasm or suspicious for a follicular neoplasm (Thy3f), 52 (3.8%) were suspicious for malignancy (Thy4), 55 (4%) were malignant (Thy5), 101 (7.4%) as Unsatisfactory (Thy1). Only 137 patients underwent thyroid surgery, and the FNAC reports were compared with their final histopathology reports. The sensitivity, specificity and total accuracy of FNAC were 80.2%, 98.9% and 89.9%, respectively. The positive and negative predictive values of FNAC were 98.6% and 84.3%, respectively.
conclusionOur study findings confirmed that FNAC of the thyroid is a sensitive, specific, and accurate initial tool for the diagnosis of thyroid lesions. Most of the FNACs were benign with a very low malignancy rate. Due to the minimal chance of false negative results and the slow-growing nature of thyroid malignancy, it is important that patients with benign FNAC should have periodic clinical and radiological follow-up. LIMITATIONS: Retrospective design and single-center study, and thyroid nodule size unavailable. CONFLICT OF INTEREST: None.
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