ArticleAging clinical and experimental research2022
The association between visceral adiposity index and leukocyte telomere length in adults: results from National Health and Nutrition Examination Survey.
Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Advanced liver fibrosis, but not MASLD, is associated with accelerated biological aging: a population-based study.BMC public health · 2024Article
- Association of visceral adiposity index with phenotypic age acceleration: insight from NHANES 1999-2010.The journal of nutrition, health & aging · 2024Article
- Associations of telomere length with risk of mortality from influenza and pneumonia in US adults: a prospective cohort study of NHANES 1999-2002.Aging clinical and experimental research · 2023Article
- A cross-sectional analysis of association between visceral adiposity index and serum anti-aging protein Klotho in adults.Frontiers in endocrinology · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLeukocyte telomere length (LTL) is a robust marker of biological aging, which is associated with obesity. Recently, the visceral adiposity index (VAI) has been proposed as an indicator of adipose distribution and function.
objectiveTo evaluated the association between VAI and LTL in adult Americans.
methodsThere were 3193 participants in U.S. National Health and Nutrition Examination Surveys (1999-2002) included in this analysis. LTL was measured using quantitative PCR (qPCR) and expressed as telomere to single-gene copy ratio (T/S ratio). We performed multiple logistic regression models to explore the association between VAI and LTL by adjusting for potential confounders.
resultsAmong all participants, VAI was associated with the shorter LTL (β: - 14.81, 95% CI - 22.28 to - 7.34, p < 0.001). There were significant differences of LTL in VAI tertiles (p < 0.001). Participants in the higher VAI tertile had the shorter LTL (1.26 ≤ VAI < 2.46: β = - 130.16, 95% CI [ - 183.44, - 76.87]; VAI ≥ 2.46: β = - 216.12, 95% CI [ - 216.12, - 81.42], p for trend: < 0.001) comparing with the lower VAI tertile. We also found a non-linear relationship between VAI and LTL. VAI was negatively correlated with LTL when VAI was less than 2.84.
conclusionsThe present study demonstrates that VAI is independently associated with telomere length. A higher VAI is associated with shorter LTL. The results suggest that VAI may provide prediction for LTL and account for accelerating the biological aging.
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