ArticleNature communications2022
A cognitive neurogenetic approach to uncovering the structure of executive functions.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Gray matter and cognitive alteration related to chronic obstructive pulmonary disease patients: combining ALE meta-analysis and MACM analysis.Brain imaging and behavior · 2025Pooled it
- Cognitive training shapes brain plasticity and schematic representations.Behavioral and brain functions : BBF · 2025Review
- Electrophysiological resting-state signatures link polygenic scores to general intelligence.Scientific reports · 2025Observational
- Dedifferentiation and Transfer in Executive Function and Math Ability Following a Five-Year Abacus Training in Schoolchildren.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Event cache: An independent component in working memory.Science advances · 2025Article
- Uncovering narrative aging: an underlying neural mechanism compensated through spatial constructional ability.Communications biology · 2025Article
- Novel Genes Associated With Working Memory Are Identified by Combining Connectome, Transcriptome, and Genome.Human brain mapping · 2025Article
- Exploring the impact of compound retrieval strategy in the task-switching paradigm.Frontiers in human neuroscience · 2025Article
- The development and validation of a tablet-based assessment battery of general cognitive ability.BMC psychology · 2024Article
- The development of cognitive flexibility and its implications for mental health disorders.Psychological medicine · 2024Article
- Task Switching: On the Relation of Cognitive Flexibility with Cognitive Capacity.Journal of Intelligence · 2023Article
- Executive functions modulate conditioned fear extinction and reinstatement: The differential roles of shifting, updating, and inhibition.International journal of clinical and health psychology : IJCHPArticle
- Risk factors for executive function impairment in adolescence: an analysis of data from the 2004 Pelotas Birth Cohort study.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One central mission of cognitive neuroscience is to understand the ontology of complex cognitive functions. We addressed this question with a cognitive neurogenetic approach using a large-scale dataset of executive functions (EFs), whole-brain resting-state functional connectivity, and genetic polymorphisms. We found that the bifactor model with common and shifting-specific components not only was parsimonious but also showed maximal dissociations among the EF components at behavioral, neural, and genetic levels. In particular, the genes with enhanced expression in the middle frontal gyrus (MFG) and the subcallosal cingulate gyrus (SCG) showed enrichment for the common and shifting-specific component, respectively. Finally, High-dimensional mediation models further revealed that the functional connectivity patterns significantly mediated the genetic effect on the common EF component. Our study not only reveals insights into the ontology of EFs and their neurogenetic basis, but also provides useful tools to uncover the structure of complex constructs of human cognition.
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