Evidence map›Paper›PMID 35933426›Full record

ArticleNature communications2022

Structural and dynamic mechanisms of GABA

Shaotong Zhu, Akshay Sridhar, Jinfeng Teng, Rebecca J Howard, Erik Lindahl, Ryan E Hibbs

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Cys-loop receptors on cannabinoids: All high?Frontiers in physiology · 2022
    Pooled it
  2. Protein-Ratio Rheostats: Integrating Stoichiometry, Abundance, and Binding Affinity in Cellular Function.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Hederagenin Attenuates Morphine Addiction via GABAA1-Mediated Modulation of CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Topography of Regional Cerebral GABAThe European journal of neuroscience · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Design, Synthesis, and Pharmacological Activity of theMolecules (Basel, Switzerland) · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Resolving native GABANature · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Shaotong ZhuDepartments of Neuroscience and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Akshay SridharDept. of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.
Jinfeng TengDepartments of Neuroscience and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Rebecca J HowardDept. of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.ORCID 0000-0003-2049-3378
Erik LindahlDept. of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.ORCID 0000-0002-2734-2794
Ryan E HibbsDepartments of Neuroscience and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. ryan.hibbs@utsouthwestern.edu.ORCID 0000-0003-4283-1147
Stockholm University · SEInstitute for Protein Innovation · USScience for Life Laboratory · SESouthwestern Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Structure and Function of GABA-A ReceptorsR01DA047325 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI Ryan E Hibbs, David W Nauen · 2019 to 2026
$4.4M
NIDA NIH HHS R01 DA047325NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

γ-Aminobutyric acid type A (GABA

Indexed as

BenzodiazepinesReceptors, GABA-ABinding SitesGABA Modulatorsgamma-Aminobutyric AcidZolpidemBenzodiazepinesGABA Modulatorsgamma-Aminobutyric AcidReceptors, GABA-AZolpidem

Identifiers

PMID35933426
PMCPMC9357065
OpenAlexW4290033833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.