Evidence map›Paper›PMID 35933372›Full record

ArticleBMC musculoskeletal disorders2022

High bone mass and cam morphology are independently related to hip osteoarthritis: findings from the High Bone Mass cohort.

B E Zucker, R Ebsim, C Lindner, S Hardcastle, T Cootes, J H Tobias, M R Whitehouse, C L Gregson, B G Faber, A E Hartley

Open access · goldAbstract read

In one paragraph

Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

1.5field-weighted citation impact, top 18% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

Osteoporosis, Osteoarthritis, and Subchondral Insufficiency Fracture: Recent Insights.Biomedicines · 2024
Review
Associations between life course longitudinal growth and hip shapes at ages 60-64 years: evidence from the MRC National Survey of Health and Development.RMD open · 2024
Article
Radiofrequency Echographic Multispectrometry (REMS) can Overcome the Effects of Structural Internal Artifacts and Evaluate Bone Fragility Accurately.Calcified tissue international · 2024
Article
Are there associations between hip geometry and bone quality? An analysis on 3074 adults from a general population.Archives of orthopaedic and trauma surgery · 2024
Article
Sex differences in the radiographic and symptomatic prevalence of knee and hip osteoarthritis.Frontiers in endocrinology · 2024
Review
Deriving alpha angle from anterior-posterior dual-energy x-ray absorptiometry scans: an automated and validated approach.Wellcome open research · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

B E ZuckerMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, l, Learning and Research Building, Level 1, Southmead Hospita, Bristol, BS10 5NB, UK.ORCID http://orcid.org/0000-0002-8085-9186

R EbsimDivision of Informatics, Imaging and Data Sciences, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-1875-5503

C LindnerDivision of Informatics, Imaging and Data Sciences, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-9396-3436

S HardcastleMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, l, Learning and Research Building, Level 1, Southmead Hospita, Bristol, BS10 5NB, UK.ORCID http://orcid.org/0000-0002-5959-4873

T CootesDivision of Informatics, Imaging and Data Sciences, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-2695-9063

J H TobiasMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, l, Learning and Research Building, Level 1, Southmead Hospita, Bristol, BS10 5NB, UK.ORCID http://orcid.org/0000-0002-7475-3932

M R WhitehouseMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, l, Learning and Research Building, Level 1, Southmead Hospita, Bristol, BS10 5NB, UK.ORCID http://orcid.org/0000-0003-2436-9024

C L GregsonMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, l, Learning and Research Building, Level 1, Southmead Hospita, Bristol, BS10 5NB, UK.ORCID http://orcid.org/0000-0001-6414-0529

B G Faber *Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, l, Learning and Research Building, Level 1, Southmead Hospita, Bristol, BS10 5NB, UK. ben.faber@bristol.ac.uk.ORCID http://orcid.org/0000-0003-4102-0190

A E Hartley *Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, l, Learning and Research Building, Level 1, Southmead Hospita, Bristol, BS10 5NB, UK.ORCID http://orcid.org/0000-0003-4932-1588

University of Bristol · GBUniversity of Manchester · GBUniversity Hospitals Bristol NHS Foundation Trust · GB

Funding

Medical Research Council MR/S021280/1Versus Arthritis 20000Wellcome TrustWellcome Trust 20378/Z/16/ZWellcome Trust 223267/Z/21/Z

6 · The paper itself

Abstract

backgroundHigh bone mass (HBM, BMD Z-score ≥ + 3.2) and cam morphology (bulging of lateral femoral head) are associated with greater odds of prevalent radiographic hip osteoarthritis (rHOA). As cam morphology is itself a manifestation of increased bone deposition around the femoral head, it is conceivable that cam morphology may mediate the relationship between HBM and rHOA. We therefore aimed to determine if individuals with HBM have increased odds of prevalent cam morphology. In addition, we investigated whether the relationship between cam and prevalent and incident osteoarthritis was preserved in a HBM population.

methodsIn the HBM study, a UK based cohort of adults with unexplained HBM and their relatives and spouses (controls), we determined the presence of cam morphology using semi-automatic methods of alpha angle derivation from pelvic radiographs. Associations between HBM status and presence of cam morphology, and between cam morphology and presence of rHOA (or its subphenotypes: osteophytes, joint space narrowing, cysts, and subchondral sclerosis) were determined using multivariable logistic regression, adjusting for age, sex, height, weight, and adolescent physical activity levels. The association between cam at baseline and incidence of rHOA after an average of 8 years was determined. Generalised estimating equations accounted for individual-level clustering.

resultsThe study included 352 individuals, of whom 235 (66.7%) were female and 234 (66.5%) had HBM. Included individuals contributed 694 hips, of which 143 had a cam deformity (20.6%). There was no evidence of an association between HBM and cam morphology (OR = 0.97 [95% CI: 0.63-1.51], p = 0.90) but a strong relationship was observed between cam morphology and rHOA (OR = 3.96 [2.63-5.98], p = 5.46 × 10

conclusionsThe relationship between cam morphology and rHOA seen in other studies is preserved in a HBM population. This study suggests that the risk of OA conferred by high BMD and by cam morphology are mediated via distinct pathways.

Indexed as

Osteoarthritis, HipOsteophyteAdolescentAdultCohort StudiesFemaleHip JointHumansMaleRadiographySclerosisBone mineral densityCam morphologyHigh Bone MassOsteoarthritis

Identifiers

PMID35933372

DOI10.1186/s12891-022-05603-3

PMCPMC9356486

OpenAlexW4289978601

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.