Evidence map›Paper›PMID 35932971›Full record

ArticleInsect biochemistry and molecular biology2022

Characterization of two kdr mutations at predicted pyrethroid receptor site 2 in the sodium channels of Aedes aegypti and Nilaparvata lugens.

Huahua Sun, Yoshiko Nomura, Yuzhe Du, Zewen Liu, Boris S Zhorov, Ke Dong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Insect biochemistry and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Plasticity in Gene Expression Patterns andInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 4 countries.

Huahua SunDepartment of Biology, Duke University, Durham, NC, USA; College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.
Yoshiko NomuraDepartment of Entomology, Michigan State University, East Lansing, MI, USA.
Yuzhe DuSouthern Insect Management Research Unit, Agriculture Research Service, United States Department of Agriculture, 141 Experiment Station Road, Stoneville, MS, 38776, USA.
Zewen LiuCollege of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.
Boris S ZhorovDepartment of Biochemistry and Biomedical Sciences, McMaster University, Canada; Sechenov Institute of Evolutionary Physiology & Biochemistry, Russian Academy of Sciences, St. Petersburg, 194223, Russia.
Ke DongDepartment of Biology, Duke University, Durham, NC, USA; Department of Entomology, Michigan State University, East Lansing, MI, USA. Electronic address: ke.dong@duke.edu.
Nanjing Agricultural University · CNDuke University · USInstitute of Evolutionary Physiology and Biochemistry · RUMichigan State University · USUnited States Department of Agriculture · US

Funding

Molecular mechanisms of action and resistance of sodium channel-targeting insectiR01GM057440 · NIGMS · MICHIGAN STATE UNIVERSITY · PI DONG, KE, HUGHSON, FREDERICK M · 1999 to 2023
$5.4M
NIGMS NIH HHS R01 GM057440
6 · The paper itself

Abstract

Pyrethroid insecticides prolong the opening of insect sodium channels by binding to two predicted pyrethroid receptor sites (PyR), PyR1 and PyR2. Many naturally-occurring sodium channel mutations that confer pyrethroid resistance (known as knockdown resistance, kdr) are located at PyR1. Recent studies identified two new mutations, V253F and T267A, at PyR2, which co-exist with two well-known mutations F1534C or M918T, at PyR1, in pyrethroid-resistant populations of Aedes aegypti and Nilaparvata lugens, respectively. However, the role of the V253F and T267A mutations in pyrethroid resistance has not been functionally examined. Here we report functional characterization of the V253F and T267A mutations in the Ae. aegypti sodium channel AaNa

Indexed as

AedesInsecticidesPyrethrinsVoltage-Gated Sodium ChannelsAnimalsInsecticide ResistanceMutationSodium ChannelsInsecticidesPyrethrinsSodium ChannelsVoltage-Gated Sodium ChannelsKnockdown resistancePyrethroid insecticidesPyrethroid receptor site 2Sodium channel

Identifiers

PMID35932971
PMCPMC10076083
OpenAlexW4289596836

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.