ArticlePhotodiagnosis and photodynamic therapy2022
Sandpaper curettage: A simple method to improve PDT outcomes for actinic keratosis.
Article in Photodiagnosis and photodynamic therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03319251 (Biomarkers of Clinical Responsiveness to Photodynamic Therapy), which is not on this map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biomarkers of Clinical Responsiveness to Photodynamic Therapy
Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Can Urea 10% Promote Photosensitizer Uptake Before MAL-PDT for the Treatment of Facial Actinic Keratoses? Results of a Randomized Clinical Trial.Photodermatology, photoimmunology & photomedicine · 2025Trial
- Painless PDT using 10% aminolevulinate gel and red light: A pilot clinical trial of short-contact protocols to reduce discomfort during illumination.Photodiagnosis and photodynamic therapy · 2025Trial
- International expert consensus on transdermal drug delivery technologies in dermatology.JAAD international · 2026Article
- Evaluation of 30% Urea Pretreatment in Enhancing the Efficacy of Photodynamic Therapy for Actinic Keratoses of the Scalp.Dermatology practical & conceptual · 2026Article
- Expert consensus-based recommendations on the use of photodynamic therapy in actinic keratosis patients.JAAD international · 2025Article
- Significant Association of Poly-A and Fok1 Polymorphic Alleles of the Vitamin D Receptor with Vitamin D Serum Levels and Incidence of Squamous Cutaneous Neoplasia.The Journal of investigative dermatology · 2023Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
introductionPhotodynamic therapy (PDT) is a non-scarring, repeatable, and safe treatment for actinic keratosis (AK), but improvements in efficacy are still needed.
backgroundDevices such as steel blades, needle rollers, and lasers are currently used to remove hypertrophic stratum corneum on AKs to improve PDT outcomes. However, curettage with fine sandpaper could be a gentler, effective alternative.
methodsA retrospective study was designed to compare PDT with or without sandpaper curettage. Patients were selected from a database registry of patients with face and scalp AKs (ClinicalTrials.gov NCT03319251). Patients in Group 1 underwent PDT alone (20% ALA, 15 min; blue light 417 nm, 30 min). Patients in Group 2 were pretreated with gentle sandpaper curettage prior to ALA and illumination. The two groups were compared using multivariate matching, normalizing for age, sex, initial AK counts, and time to follow-up.
resultsSixty-six patients were selected for matching analysis (n=38, PDT only; n=28, PDT+curettage). Demographics between the groups were similar (mean ± SD), including age (71.0 ± 8.3 vs. 71.0 ± 8.0 years), baseline AK count (53 ± 39 vs. 44± 32), and time to post-PDT follow-up (111 ± 28 vs. 113 ± 32 days). At follow-up, patients who received curettage showed an overall 55% improvement in scalp AK clearance compared to patients who did not receive curettage, adjusting for sex, age, time to follow-up, and baseline AK count (p = 0.0322, multivariable linear regression). DISCUSSION: Sandpaper curettage before PDT treatment is an easy and inexpensive method to significantly improve AK clearance rates.
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