Evidence map›Paper›PMID 35932933›Full record

ArticleInternational journal of pharmaceutics2022

Tumoral oxygenation and biodistribution of Lonidamine oxygen microbubbles following localized ultrasound-triggered delivery.

Quezia Lacerda, Ankit Rochani, Brian Oeffinger, Ji-Bin Liu, Corinne E Wessner, Aylin Tahmasebi, Hebah Falatah, Philip Lee, Dennis B Leeper, Flemming Forsberg and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Quezia LacerdaDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA; School of Biomedical Engineering, Science and Heath Systems, Drexel University, Philadelphia, PA 19104, USA.
Ankit RochaniDepartment of Pharmaceutical Sciences, Thomas Jefferson University, Philadelphia, PA 19107, USA; Wegmans School of Pharmacy, Department of Pharmaceutical Sciences, St. John Fisher University, Rochester, NY 14618, USA.
Brian OeffingerSchool of Biomedical Engineering, Science and Heath Systems, Drexel University, Philadelphia, PA 19104, USA.
Ji-Bin LiuDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Corinne E WessnerDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA; School of Biomedical Engineering, Science and Heath Systems, Drexel University, Philadelphia, PA 19104, USA.
Aylin TahmasebiDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Hebah FalatahDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA; School of Biomedical Engineering, Science and Heath Systems, Drexel University, Philadelphia, PA 19104, USA.
Philip LeeDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Dennis B LeeperDepartment of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Flemming ForsbergDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Joseph CurryDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Scott W KeithDivision of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Patrick O'KaneDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Gagan KaushalDepartment of Pharmaceutical Sciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Margaret A WheatleySchool of Biomedical Engineering, Science and Heath Systems, Drexel University, Philadelphia, PA 19104, USA.
John R EisenbreyDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: john.eisenbrey@jefferson.edu.
Thomas Jefferson University · USDrexel University · US

Funding

Clinically Translatable Ultrasound-Sensitive Microbubble Approaches for Overcoming Tumor HypoxiaR01EB026881 · NIBIB · THOMAS JEFFERSON UNIVERSITY · PI EISENBREY, JOHN, WHEATLEY, MARGARET A. · 2018 to 2021
$2.5M
Vevo 3100 ultrasound scanner and PV loop systemS10OD030483 · OD · THOMAS JEFFERSON UNIVERSITY · PI FORSBERG, FLEMMING · 2021 to 2021
$747k
NIBIB NIH HHS R01 EB026881NIH HHS S10 OD030483
6 · The paper itself

Abstract

Prior work has shown that microbubble-assisted delivery of oxygen improves tumor oxygenation and radiosensitivity, albeit over a limited duration. Lonidamine (LND) has been investigated because of its ability to stimulate glycolysis, lactate production, inhibit mitochondrial respiration, and inhibit oxygen consumption rates in tumors but suffers from poor bioavailability. The goal of this work was to characterize LND-loaded oxygen microbubbles and assess their ability to oxygenate a human head and neck squamous cell carcinoma (HNSCC) tumor model, while also assessing LND biodistribution. In tumors treated with surfactant-shelled microbubbles with oxygen core (SE61O

Indexed as

MicrobubblesNeoplasmsHumansIndazolesOxygenTissue DistributionIndazoleslonidamineOxygenContrast-enhanced ultrasoundDrug deliveryHead and neck cancerHypoxiaLonidamineMicrobubblesOxygen delivery

Identifiers

PMID35932933
PMCPMC9748847
OpenAlexW4289596125

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.