ArticleCell reports. Medicine2022
Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy.
Article in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
- Gut microbial bile and amino acid metabolism associate with peanut oral immunotherapy failure.Nature communications · 2025Trial
- The Michigan Sibling Immunity Birth Study (M-SIBS): Study design protocol for a unique food allergy birth cohort.The journal of allergy and clinical immunology. Global · 2026Article
- Antibiotic Exposure Through Human Milk Influences the Infant Gut Microbiome.bioRxiv : the preprint server for biology · 2026Article
- The gut microbiome in early life predicts malaria susceptibility.Frontiers in cellular and infection microbiology · 2026Article
- Vaginal microbiome structure in pregnancy and host factors predict preterm birth: Results from the ECHO Cohort.Annals of epidemiology · 2025Article
- Distinct Risk Factors Contribute to Variations in Early Life Eczema Prevalence in Ethnically Chinese Children From Shanghai and Singapore.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Lactobacillus crispatus KBL693 alleviates atopic dermatitis symptoms through immune modulation.Journal of microbiology (Seoul, Korea) · 2025Article
- Gynecological health: A missing link in comprehensive treatment monitoring for multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Review
- Tuo-Min-Ding-Chuan Decoction Alleviates Asthma via Spatial Regulation of Gut Microbiota and Treg Cell Promotion.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Maternal vaginal and fecal microbiota in later pregnancy contribute to child fecal microbiota development in the ECHO cohort.iScience · 2025Article
- Clinical translation of microbiome research.Nature medicine · 2025Review
- Impact of Early-Life Microbiota on Immune System Development and Allergic Disorders.Biomedicines · 2025Review
- The vaginal microbiome in HPV persistence and cervical cancer progression.Frontiers in cellular and infection microbiology · 2025Review
- The human microbiome in clinical translation: from bench to bedside.Frontiers in microbiology · 2025Review
- Fecal microbiota is associated with extraintestinal manifestations in inflammatory bowel disease.Annals of medicine · 2024Article
- Sustained mucosal colonization and fecal metabolic dysfunction by Bacteroides associates with fecal microbial transplant failure in ulcerative colitis patients.Scientific reports · 2024Article
- The gut-airway microbiome axis in health and respiratory diseases.Nature reviews. Microbiology · 2024Review
- Prevention of IgE-Mediated Food Allergy: Emerging Strategies Through Maternal and Neonatal Interventions.The journal of allergy and clinical immunology. In practice · 2024Review
- Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium.Scientific reports · 2024Article
- Influence of infant microbiome on health and development.Clinical and experimental pediatrics · 2024Article
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 1 country.
Funding
Abstract
Maternal asthma status, prenatal exposures, and infant gut microbiota perturbation are associated with heightened risk of atopy and asthma risk in childhood, observations hypothetically linked by intergenerational microbial transmission. Using maternal vaginal (n = 184) and paired infant stool (n = 172) samples, we identify four compositionally and functionally distinct Lactobacillus-dominated vaginal microbiota clusters (VCs) that relate to prenatal maternal health and exposures and infant serum immunoglobulin E (IgE) status at 1 year. Variance in bacteria shared between mother and infant pairs relate to VCs, maternal allergy/asthma status, and infant IgE levels. Heritable bacterial gene pathways associated with infant IgE include fatty acid synthesis and histamine and tryptophan degradation. In vitro, vertically transmitted Lactobacillus jensenii strains induce immunosuppressive phenotypes on human antigen-presenting cells. Murine supplementation with L. jensenii reduces lung eosinophils, neutrophilic expansion, and the proportion of interleukin-4 (IL-4)
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.