ArticleJournal of the neurological sciences2022
Decreased vestibular efficacy contributes to abnormal balance in Parkinson's disease.
Article in Journal of the neurological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Beyond motor: a systematic review of multisensory integration deficits in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Pooled it
- Vestibular Dysfunction in Parkinson's Disease: A Systematic Review of Signs and Symptoms.Movement disorders clinical practice · 2026Pooled it
- Neuroimaging and cognitive correlates of postural control in Parkinson's disease: a systematic review.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Associations Between the Vestibulo-Ocular Reflex and Cognitive Function in de novo Parkinson's Disease.Journal of movement disorders · 2026Article
- Examining Sensory Systems That Contribute to Falls in Parkinson Disease Using Computerized Dynamic Posturography: Secondary Analysis.JMIR formative research · 2026Article
- The central cholinergic system as a therapeutic target in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Associations Between Vestibular Function and White Matter Microstructure in Healthy Older Adults.medRxiv : the preprint server for health sciences · 2025Article
- Reduced Vestibular Function is Associated With Cortical Surface Shape Changes in the Frontal Cortex.Human brain mapping · 2025Article
- Bilateral alterations in sensorimotor function and altered sensory strategy in individuals with unilateral chronic ankle instability.Journal of exercise science and fitness · 2025Article
- Supervised-not voluntary-upper limb exercise enhances vestibular function in Parkinson's disease.Frontiers in neurology · 2025Article
- Reduced Vestibular Function is Associated with Cortical Surface Shape Changes in the Frontal Cortex.medRxiv : the preprint server for health sciences · 2024Article
- Neck rigidity: a pitfall for video head-impulse tests in Parkinson's disease.Journal of neurology · 2024Article
- Vestibular-evoked myogenic potential abnormalities in Parkinson's disease with freezing of gait.Journal of neurology · 2024Article
- Vestibular dysfunction in Parkinson's disease: a neglected topic.Frontiers in neurology · 2024Review
- Cholinergic system correlates of postural control changes in Parkinson's disease freezers.Brain : a journal of neurology · 2023Article
- Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson's Disease.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeAbnormal balance is poorly responsive to dopaminergic therapy in Parkinson's disease (PD). Decreased vestibular efficacy may contribute to imbalance in PD. The purpose of this study was to investigate the relationship between vestibular measures of dynamic posturography and imbalance in PD while accounting for confounder variables.
methods106 patients with PD underwent dynamic posturography for the 6 conditions of the sensory integration test (SOT) using the Neurocom Equitest device. All SOT measures, nigrostriatal dopaminergic denervation ((+)-[
resultsThe presence of imbalance was significantly associated with vestibular ratio COP RMS (P = 0.002) independently from visual ratio COP velocity (P = 0.012), thalamic acetylcholinesterase activity (P = 0.0032), cognition (P = 0.006), motor severity (P = 0.0039), age (P = 0.001), ankle vibration sensitivity (P = 0.0008), and borderline findings for somatosensory ratio COP velocity (P = 0.074) and visual ratio COP RMS (P = 0.078). Nigrostriatal dopaminergic denervation did not achieve significance.
conclusionsThe inability to efficaciously utilize vestibular information to retain upright stance is a determinant of imbalance in PD independent from visual and somatosensory processing changes and nigrostriatal dopaminergic losses. Thalamic, but not cortical, cholinergic denervation incrementally predicted balance abnormality. Further research is needed to investigate an intrinsic role of the cholinergic thalamus in multi-sensory, in particular vestibular, processing functions of postural control in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.