SynthesisJournal of nephrology2022
Incidence, severity, risk factors and outcomes of acute kidney injury in older adults: systematic review and meta-analysis.
Synthesis in Journal of nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 23 citations in OpenAlex.
- Concurrent use of medicines with similar adverse drug reaction profiles in older adults: identifying potential deprescribing opportunities using population-level dispensing data.International journal of clinical pharmacy · 2026Article
- Prevalence and risk factors of acute kidney injury in patients with hip fractures.Journal of perioperative practice · 2026Observational
- Explainable machine learning-based 28-day mortality prediction model for elderly patients with acute kidney injury.BMC nephrology · 2026Article
- Incidence and risk factors of acute kidney injury after myocardial infarction; a prospective cohort study with impact of timing of presentation on other risk factors.BMC nephrology · 2026Article
- Review
- Identification of Risk Factors and Prediction Models for Acute Kidney Injury in Hospitalized Elderly Patients with Heart Failure.Clinical interventions in aging · 2026Article
- A case/non-case study of a national pharmacovigilance database to explore drug-induced acute kidney injury.International journal of clinical pharmacy · 2025Article
- Heart failure subphenotypes based on mean arterial pressure trajectory identify patients at increased risk of acute kidney injury.Renal failure · 2025Article
- Transfusion Thresholds and Risk Factors of Acute Kidney Injury in Gastrointestinal Oncology Surgery: Insights from a Retrospective Study.Healthcare (Basel, Switzerland) · 2025Article
- Leveraging Large Language Models for Predicting Postoperative Acute Kidney Injury in Elderly Patients.BME frontiers · 2025Article
- Article
- Differences in characteristics and risk factors for acute kidney injury between elderly and very elderly patients: a retrospective review.Clinical and experimental nephrology · 2024Observational
- A pharmacovigilance study on clinical factors of active vitamin DScientific reports · 2024Article
- Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism.JCI insight · 2024Article
- Effects of inpatient creatinine testing frequency on acute kidney injury identification and staging: a historical cohort study.International journal of clinical pharmacy · 2024Article
- Outcome Comparison in Hospitalized COVID-19 Patients With and Without AKI.Journal of community hospital internal medicine perspectives · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOld age was identified as a strong risk factor for acute kidney injury (AKI). Our objectives were to provide estimates of AKI, risk factors and outcomes in patients ≥ 75 years for whom data are scarce.
methodsObservational studies and randomized controlled trials between 2005 and 2021 with patients of mean or median age ≥ 75 years, reporting AKI according to current definitions. Data on AKI incidence, risk factors and mortality were analyzed separately in unselected (UC) and acute heart failure (AHF) cohorts.
resultsTwenty-six observational studies and 4 randomized controlled trials with 51,111 UC and 25,414 AHF patients were included. Ages averaged 79.4 and 79.8 years, respectively. Pooled risk ratios (RRs) of AKI rates were 26.29% (95% confidence intervals (CI) 13.20-41.97) (UC) and 24.21% (95% CI 20.03-28.65) (AHF). In both cohorts, AKI was associated with decreased estimated glomerular filtration rate at baseline, chronic kidney disease (UC: RR 1.80 (95% CI 1.15-2.80), AHF: RR 1.51 (95% CI 1.26-1.95) and hypertension (UC: RR 1.30 (95% CI 1.09-1.56), AHF: RR 1.07 (95% CI 1.05-1.09). RRs of AKI in patients on renin-angiotensin-inhibitors were 0.87 (95% CI 0.78-0.97) and 0.88 (95% CI 0.78-0.98) in UC and AHF, respectively. AKI was consistently associated with increased risk of in-hospital mortality (UC: RR 3.15 (95% CI 2.28-4.35), AHF: RR 4.28 (95% CI 2.53-7.24).
conclusionAKI is frequent in patients ≥ 75 years. While reduced renal function at baseline, CKD and hypertension were associated with AKI development, renin-angiotensin-inhibitors may be protective. Older AKI patients showed higher short-term mortality rates.
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