Evidence map›Paper›PMID 35932310›Full record

ArticleBrain structure & function2022

Presence or absence of a prefrontal sulcus is linked to reasoning performance during child development.

Ethan H Willbrand, Willa I Voorhies, Jewelia K Yao, Kevin S Weiner, Silvia A Bunge

Open access · hybridAbstract read
In one paragraph

Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Sulcal anatomy of ventral temporal cortex and reading development.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Variable Presence of an Evolutionarily New Brain Structure Is Related to Trait Impulsivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
  6. Considerations for conducting developmental neuroimaging research on mental health topics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  7. Anchoring Functional Connectivity to Individual Sulcal Morphology Yields Insights in a Pediatric Study of Reasoning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Article
  10. Emotion-related impulsivity is related to orbitofrontal cortical sulcation.Cortex; a journal devoted to the study of the nervous system and behavior · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Defining Overlooked Structures Reveals New Associations between the Cortex and Cognition in Aging and Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ethan H WillbrandDepartment of Psychology, University of California Berkeley, Berkeley, CA, 94720, USA.
Willa I VoorhiesDepartment of Psychology, University of California Berkeley, Berkeley, CA, 94720, USA.
Jewelia K YaoPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, 08540, USA.
Kevin S Weiner *Department of Psychology, University of California Berkeley, Berkeley, CA, 94720, USA. kweiner@berkeley.edu.ORCID http://orcid.org/0000-0002-8734-5049
Silvia A Bunge *Department of Psychology, University of California Berkeley, Berkeley, CA, 94720, USA.
University of California, Berkeley · USPrinceton University · US

Funding

Neuroscience Training Program at UC BerkeleyT32NS095939 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BATEUP, HELEN S. · 2016 to 2025
$6.3M
The role of prefrontal sulcal morphology and brain network architecture in cognitive developmentR21HD100858 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI BUNGE, SILVIA A., WEINER, KEVIN SEAN · 2020 to 2021
$375k
NICHD NIH HHS R21 HD100858NINDS NIH HHS R01NS057156NINDS NIH HHS T32 NS095939
6 · The paper itself

Abstract

The relationship between structural variability in late-developing association cortices like the lateral prefrontal cortex (LPFC) and the development of higher-order cognitive skills is not well understood. Recent findings show that the morphology of LPFC sulci predicts reasoning performance; this work led to the observation of substantial individual variability in the morphology of one of these sulci, the para-intermediate frontal sulcus (pimfs). Here, we sought to characterize this variability and assess its behavioral significance. To this end, we identified the pimfs in a developmental cohort of 72 participants, ages 6-18. Subsequent analyses revealed that the presence or absence of the ventral component of the pimfs was associated with reasoning, even when controlling for age. This finding shows that the cortex lining the banks of sulci can support the development of complex cognitive abilities and highlights the importance of considering individual differences in local morphology when exploring the neurodevelopmental basis of cognition.

Indexed as

Child DevelopmentMagnetic Resonance ImagingAdolescentCerebral CortexChildCognitionHumansPrefrontal CortexBrain imagingCortical foldingNeuroanatomyNeurodevelopmentPrefrontal cortexReasoningSulcal pattern

Identifiers

PMID35932310
PMCPMC9418286
OpenAlexW4290000806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.